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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rbm15tm1.1Dgg
targeted mutation 1.1, D Gary Gilliland
MGI:3706995
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rbm15tm1.1Dgg/Rbm15tm1.1Dgg involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:3710770
cn2
 		Rbm15tm1Dgg/Rbm15tm1.1Dgg
Tg(Mx1-cre)1Cgn/0 		involves: 129/Sv * C57BL/6 * CBA * FVB/N MGI:3710771


Genotype
MGI:3710770
hm1
Allelic
Composition		 Rbm15tm1.1Dgg/Rbm15tm1.1Dgg
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbm15tm1.1Dgg mutation (0 available); any Rbm15 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:120321 )
• embryos after E9.5 showed degeneration and resorption




Genotype
MGI:3710771
cn2
Allelic
Composition		 Rbm15tm1Dgg/Rbm15tm1.1Dgg
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbm15tm1.1Dgg mutation (0 available); any Rbm15 mutation (30 available)
Rbm15tm1Dgg mutation (0 available); any Rbm15 mutation (30 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell differentiation ( J:120321 )
• after Poly(I) Poly(C) induction of cre expression in 6 week old mice, bone marrow shows 10 fold fewer pre-B cells, indicating a block in pre/pre-B differentiation
increased megakaryocyte cell number ( J:120321 )
• after Poly(I) Poly(C) induction of cre expression in 6 week old mice, 2 fold increase in megakaryocytes is observed
decreased B cell number ( J:120321 )
• after Poly(I) Poly(C) induction of cre expression in 6 week old mice, the total WBC count gradually decreases over a 6 week period resulting from a striking decline in peripheral B lymphocytes
decreased pre-B cell number ( J:120321 )
• after Poly(I) Poly(C) induction of cre expression in 6 week old mice, bone marrow shows 10 fold fewer pre-B cells
increased hematopoietic stem cell number ( J:120321 )
• after Poly(I) Poly(C) induction of cre expression in 6 week old mice, an increase in the hematopoietic stem cells and shift in progenitor fate toward granulocyte differentiation is observed
increased spleen red pulp amount ( J:120321 )
• after Poly(I) Poly(C) induction of cre expression in 6 week old mice, an expansion of the splenic red pulp is observed

immune system
abnormal B cell differentiation ( J:120321 )
• after Poly(I) Poly(C) induction of cre expression in 6 week old mice, bone marrow shows 10 fold fewer pre-B cells, indicating a block in pre/pre-B differentiation
decreased B cell number ( J:120321 )
• after Poly(I) Poly(C) induction of cre expression in 6 week old mice, the total WBC count gradually decreases over a 6 week period resulting from a striking decline in peripheral B lymphocytes
decreased pre-B cell number ( J:120321 )
• after Poly(I) Poly(C) induction of cre expression in 6 week old mice, bone marrow shows 10 fold fewer pre-B cells
increased spleen red pulp amount ( J:120321 )
• after Poly(I) Poly(C) induction of cre expression in 6 week old mice, an expansion of the splenic red pulp is observed




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory