Analysis Tools
reproductive system
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• at 6 weeks of age, pyknotic germ cells in the seminiferous tubules in testis indicative of spermatogonia and spermatocyte cell death
• at 10 weeks of age, severe wasting and dramatically reduced cellularity was visible macroscopically; entirely devoid of all germ cells and their derivatives
• at 3 weeks of age, the developing germ lineage in the seminiferous tubules was completely indistinguishable from control animals
• at 10 weeks of age, Sertoli cells in the seminiferous tubules and cells of interstitium were normal
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behavior/neurological
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• exhibit a variety of symptoms of Schwann cell dysfunction including gait abnormalities beginning at 3 month of age
• mutant were viable and healthy and displayed no signs of neuropathy or myelin dysfunction into early adulthood up to 3 month of age
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growth/size/body
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• beginning at 3 month of age, pronounced in the hind limbs suggestive of neuropathy and subsequent neurogenic muscular atrophy
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nervous system
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• at 3 months of age, the mutant exhibited a marked increase in Schwann lineage proliferation
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• beginning at 3 month of age, large diameter axons completely denuded of myelin are present in sciatic nerves
• by 5 month of age, essentially all of the myelinated axons shows signs of extensive demyelination
• sciatic nerves from mutant animals at 1 month and 2 month of age showed normal myelin thickness compared to axonal diameter indicating myelinating Schwann cells are capable of attaining and a mature myelinated phenotype
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