Phenotypes associated with this allele

• Allele Symbol: Hnrnpll^thdr
• Allele Name: thunder
• Allele ID: MGI:3707008
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hnrnpll^thdr/Hnrnpll^thdr	C57BL/6JSfdAnu-Hnrnpll^thdr/Anu	MGI:3823078

Genotype
MGI:3823078

hm1

• Allelic Composition: Hnrnpll^thdr/Hnrnpll^thdr
• Genetic Background: C57BL/6JSfdAnu-Hnrnpll^thdr/Anu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:142641 )

• thymic T cell subsets are normal with the exception of high expression of the CD45 isoforms RA and RC that are not expressed on wild-type thymoctes

• nave CD44^lo T cells fail to accumulate in the periphery as the mice age

• CD44^hi memory T cells compensate for peripheral T cell lymphopenia by homeostatic proliferation leading to an increase in the percentage of memory CD4 T cells

decreased CD4-positive, alpha-beta T cell number ( J:142641 )

• the overall CD4⁺ T cell number is reduced in these mice

abnormal memory T cell morphology ( J:142641 )

• the percentage of peripheral T cells expressing the memory marker CD44^hi is increased about 4-fold in the periphery of mice over 12 weeks of age

• this increase in CD44^hi memory T cells is secondary to a loss of nave CD44^lo T cells

• the RA and RB isoforms of CD45, normally not expressed on memory T cells, are very highly expressed on the CD4⁺ memory T cells

abnormal memory T cell physiology ( J:142641 )

• memory T cells are defective in generating transcripts with alternative splices or promoters from numerous genes including the Ptprc gene (CD45)

hematopoietic system

abnormal T cell differentiation ( J:142641 )

• thymic T cell subsets are normal with the exception of high expression of the CD45 isoforms RA and RC that are not expressed on wild-type thymoctes

• nave CD44^lo T cells fail to accumulate in the periphery as the mice age

• CD44^hi memory T cells compensate for peripheral T cell lymphopenia by homeostatic proliferation leading to an increase in the percentage of memory CD4 T cells

decreased CD4-positive, alpha-beta T cell number ( J:142641 )

• the overall CD4⁺ T cell number is reduced in these mice

abnormal memory T cell morphology ( J:142641 )

• the percentage of peripheral T cells expressing the memory marker CD44^hi is increased about 4-fold in the periphery of mice over 12 weeks of age

• this increase in CD44^hi memory T cells is secondary to a loss of nave CD44^lo T cells

• the RA and RB isoforms of CD45, normally not expressed on memory T cells, are very highly expressed on the CD4⁺ memory T cells

abnormal memory T cell physiology ( J:142641 )

• memory T cells are defective in generating transcripts with alternative splices or promoters from numerous genes including the Ptprc gene (CD45)