Analysis Tools
mortality/aging
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• homozygotes often die within 2 weeks of birth
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growth/size/body
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• neonates show severe growth retardation
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immune system
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• fetal thymus shows ~15-fold reduction in cellularity
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• thymocyte number is reduced 10-fold relative to Tcf12tm1Zhu homozygotes and 100-fold relative to controls in 2-3 week old mice
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• B cell development is impaired
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• numbers of immature B cells are reduced compared to controls, but no abnormalities are observed in the peripheral lymph organs
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• numbers of pro-b cells are reduced compared to controls, but no abnormalities are observed in the peripheral lymph organs
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• T cell development is severely disrupted in peripheral and central lymph organs
• developmental defects in T cells are specific to the alpha/beta lineage, as gamma/delta T cells are detected, although at a reduced number relative to controls
• cells at the double negative 3 (DN3) stage in mutants show severe impairments of V to DJ rearrangements at the TCRbeta locus, in contrast to Tcf12tm1Zhu homozygotes or control wild-type
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• fetal thymus shows an accumulation of double negative (DN) T cells compared to controls
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• double positive (DP) T cells are nearly absent in the fetal thymus
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• defects in T cell development are also seen in the postnatal thymus
• a much tighter and earlier block in development is seen compared to Tcf12tm1Zhu homozygotes; T cell development is almost completely blocked at the double negative stage
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• numbers of pre-b cells are reduced compared to controls, but no abnormalities are observed in the peripheral lymph organs
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• single positive (SP) T cells are nearly absent in the fetal thymus
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• bone marrow cells from neonatal animals transferred to irradiated hosts are able to protect hosts from lethal irradiation, produce myeloid cells, and produce B cells at a reduced efficiency, but T cell development of transferred cells is severely impaired
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hematopoietic system
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• fetal thymus shows ~15-fold reduction in cellularity
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• thymocyte number is reduced 10-fold relative to Tcf12tm1Zhu homozygotes and 100-fold relative to controls in 2-3 week old mice
|
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• B cell development is impaired
|
|
• numbers of immature B cells are reduced compared to controls, but no abnormalities are observed in the peripheral lymph organs
|
|
• numbers of pro-b cells are reduced compared to controls, but no abnormalities are observed in the peripheral lymph organs
|
|
• T cell development is severely disrupted in peripheral and central lymph organs
• developmental defects in T cells are specific to the alpha/beta lineage, as gamma/delta T cells are detected, although at a reduced number relative to controls
• cells at the double negative 3 (DN3) stage in mutants show severe impairments of V to DJ rearrangements at the TCRbeta locus, in contrast to Tcf12tm1Zhu homozygotes or control wild-type
|
|
• fetal thymus shows an accumulation of double negative (DN) T cells compared to controls
|
|
• double positive (DP) T cells are nearly absent in the fetal thymus
|
|
• defects in T cell development are also seen in the postnatal thymus
• a much tighter and earlier block in development is seen compared to Tcf12tm1Zhu homozygotes; T cell development is almost completely blocked at the double negative stage
|
|
• numbers of pre-b cells are reduced compared to controls, but no abnormalities are observed in the peripheral lymph organs
|
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• single positive (SP) T cells are nearly absent in the fetal thymus
|
nervous system
exencephaly
(
J:120411
)
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• some homozygous fetuses display exencephaly
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endocrine/exocrine glands
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• fetal thymus shows ~15-fold reduction in cellularity
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• thymocyte number is reduced 10-fold relative to Tcf12tm1Zhu homozygotes and 100-fold relative to controls in 2-3 week old mice
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