About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Runx1tm4Spe
targeted mutation 4, Nancy A Speck
MGI:3707165
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Runx1tm4Spe/Runx1tm4Spe involves: 129/Sv * C57BL/6 MGI:3709745
ht2
 		Runx1tm4Spe/Runx1+ involves: 129/Sv * C57BL/6 MGI:3709727


Genotype
MGI:3709745
hm1
Allelic
Composition		 Runx1tm4Spe/Runx1tm4Spe
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm4Spe mutation (0 available); any Runx1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:120100 )
• fail to thrive after birth, but fifty percent of T149A/T149A mice survived past weaning, overcame their early growth disadvantage, and had a normal lifespan

embryo

growth/size/body
postnatal growth retardation ( J:120100 )

hematopoietic system

immune system




Genotype
MGI:3709727
ht2
Allelic
Composition		 Runx1tm4Spe/Runx1+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm4Spe mutation (0 available); any Runx1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryonic hematopoiesis ( J:120100 )
• aorta/gonad/mesonephros (AGM) regions have significantly more CFU-C than those in Runx1tm1Spe/+ fetuses
• fetal liver CFU-C numbers are significantly higher than in Runx1tm1Spe/+ fetuses

hematopoietic system
abnormal embryonic hematopoiesis ( J:120100 )
• aorta/gonad/mesonephros (AGM) regions have significantly more CFU-C than those in Runx1tm1Spe/+ fetuses
• fetal liver CFU-C numbers are significantly higher than in Runx1tm1Spe/+ fetuses
decreased CD4-positive, alpha-beta T cell number ( J:120100 )
• a significant decrease in percentage of CD4+ splenic T cells, and in the CD4+:CD8+ ratio is observed compared to wild-type adults, but percentage of CD8+ T cells is not changed

immune system
decreased CD4-positive, alpha-beta T cell number ( J:120100 )
• a significant decrease in percentage of CD4+ splenic T cells, and in the CD4+:CD8+ ratio is observed compared to wild-type adults, but percentage of CD8+ T cells is not changed




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory