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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Runx1tm4Spe
targeted mutation 4, Nancy A Speck
MGI:3707165
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Runx1tm4Spe/Runx1tm4Spe involves: 129/Sv * C57BL/6 MGI:3709745
ht2
 		Runx1tm4Spe/Runx1+ involves: 129/Sv * C57BL/6 MGI:3709727


Genotype
MGI:3709745
hm1
Allelic
Composition		 Runx1tm4Spe/Runx1tm4Spe
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm4Spe mutation (0 available); any Runx1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:120100 )
• fail to thrive after birth, but fifty percent of T149A/T149A mice survived past weaning, overcame their early growth disadvantage, and had a normal lifespan

embryo

growth/size/body
postnatal growth retardation ( J:120100 )

hematopoietic system

immune system




Genotype
MGI:3709727
ht2
Allelic
Composition		 Runx1tm4Spe/Runx1+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm4Spe mutation (0 available); any Runx1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryonic hematopoiesis ( J:120100 )
• aorta/gonad/mesonephros (AGM) regions have significantly more CFU-C than those in Runx1tm1Spe/+ fetuses
• fetal liver CFU-C numbers are significantly higher than in Runx1tm1Spe/+ fetuses

hematopoietic system
abnormal embryonic hematopoiesis ( J:120100 )
• aorta/gonad/mesonephros (AGM) regions have significantly more CFU-C than those in Runx1tm1Spe/+ fetuses
• fetal liver CFU-C numbers are significantly higher than in Runx1tm1Spe/+ fetuses
decreased CD4-positive, alpha-beta T cell number ( J:120100 )
• a significant decrease in percentage of CD4+ splenic T cells, and in the CD4+:CD8+ ratio is observed compared to wild-type adults, but percentage of CD8+ T cells is not changed

immune system
decreased CD4-positive, alpha-beta T cell number ( J:120100 )
• a significant decrease in percentage of CD4+ splenic T cells, and in the CD4+:CD8+ ratio is observed compared to wild-type adults, but percentage of CD8+ T cells is not changed




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/24/2024
MGI 6.24 		The Jackson Laboratory