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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Runx1tm8Spe
targeted mutation 8, Nancy A Speck
MGI:3707173
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Runx1tm8Spe/Runx1tm8Spe involves: 129/Sv * C57BL/6 MGI:3709737
ht2
 		Runx1tm8Spe/Runx1+ involves: 129/Sv * C57BL/6 MGI:3709731


Genotype
MGI:3709737
hm1
Allelic
Composition		 Runx1tm8Spe/Runx1tm8Spe
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm8Spe mutation (0 available); any Runx1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:120100 )
• animals are same size as wild-type and heterozygous littermates at birth, but fail to thrive and die usually around 2 weeks of age, with none reaching weaning age

embryo
abnormal embryonic hematopoiesis ( J:120100 )
• at E11.5, animals have no AGM CFU-C, but there are detectable fetal liver CFU-C

growth/size/body
postnatal growth retardation ( J:120100 )
• mice become severely stunted in growth after birth

hematopoietic system
abnormal embryonic hematopoiesis ( J:120100 )
• at E11.5, animals have no AGM CFU-C, but there are detectable fetal liver CFU-C

immune system
lung inflammation ( J:120100 )
• some neonates are found to have suppurative bronchopneumonia with anterior distribution of neutrophilic infiltrates

respiratory system
lung inflammation ( J:120100 )
• some neonates are found to have suppurative bronchopneumonia with anterior distribution of neutrophilic infiltrates




Genotype
MGI:3709731
ht2
Allelic
Composition		 Runx1tm8Spe/Runx1+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1tm8Spe mutation (0 available); any Runx1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryonic hematopoiesis ( J:120100 )
• fetal liver CFU-C numbers are significantly higher than in Runx1tm1Spe/+ fetuses

hematopoietic system
abnormal embryonic hematopoiesis ( J:120100 )
• fetal liver CFU-C numbers are significantly higher than in Runx1tm1Spe/+ fetuses
decreased CD4-positive, alpha-beta T cell number ( J:120100 )
• a significant decrease in percentage of CD4+ splenic T cells, and in the CD4+:CD8+ ratio is observed compared to wild-type adults, but percentage of CD8+ T cells is not changed

immune system
decreased CD4-positive, alpha-beta T cell number ( J:120100 )
• a significant decrease in percentage of CD4+ splenic T cells, and in the CD4+:CD8+ ratio is observed compared to wild-type adults, but percentage of CD8+ T cells is not changed




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory