Phenotypes associated with this allele

• Allele Symbol: Cebpa^tm6Nerl
• Allele Name: targeted mutation 6, Claus Nerlov
• Allele ID: MGI:3707191
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cebpa^tm6Nerl/Cebpa^tm6Nerl	involves: 129P2/OlaHsd * C57BL/6	MGI:3709596

Genotype
MGI:3709596

hm1

• Allelic Composition: Cebpa^tm6Nerl/Cebpa^tm6Nerl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

decreased liver glycogen level ( J:120098 )

• hepatic glycogen levels are decreased in fed mutants

abnormal liver physiology ( J:120098 )

• GSK3 consensus phosphorylation is absent in livers of fed mutants, but is observed in adipose and lung tissue

• mRNAs for glucose-6-phosphatase (G6Pc), insulin-like growth factor binding protein-1 (IGFBP-1), phosphenol pyruvate carboxykinase (PEPCK), and tyrosine aminotransferase (TAT) are upregulated significantly in mutants; these genes have insulin response element (IRE) sequences in their promoters

homeostasis/metabolism

increased circulating glucose level ( J:120098 )

• small but significant increase is seen in fed or fasted mutants compared to wild-type

abnormal circulating insulin level ( J:120098 )

• small but significant increase is seen in mutants compared to controls

impaired glucose tolerance ( J:120098 )

• mice display significant glucose intolerance compared to controls

decreased liver glycogen level ( J:120098 )

• hepatic glycogen levels are decreased in fed mutants

adipose tissue

adipose tissue phenotype ( J:120098 )

N • no differences in amount or appearance of white adipose tissue in seem relative to wild-type

decreased adipocyte glucose uptake ( J:120098 )

• glucose uptake is lowered compared with controls

muscle

decreased skeletal muscle cell glucose uptake ( J:120098 )

• glucose uptake in skeletal muscle is significantly lowered compared with controls

respiratory system

respiratory system phenotype ( J:120098 )

N • lung tissue is normal in amount and morphology relative to wild-type

hematopoietic system

hematopoietic system phenotype ( J:120098 )

N • granulopoiesis is normal in mice relative to wild-type

cellular

decreased adipocyte glucose uptake ( J:120098 )

• glucose uptake is lowered compared with controls

decreased skeletal muscle cell glucose uptake ( J:120098 )

• glucose uptake in skeletal muscle is significantly lowered compared with controls