Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ddb2tm1Vri targeted mutation 1, Harry Vrieling MGI:3707217 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mouse dermal fibroblast cultures, treated with 5 J/m2 UV-C radiation, exhibit a delay in repair of pyrimidine(6-4)pyrimidone photoproducts with no repair occurring in the first hour after exposure
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 50% of mice develop squamous cell carcinomas larger than 1mm by week 10 and yields of squamous cell carcinomas larger than 1 and 2 mm are increased following a daily dose of 250 J/m2
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• mice exhibit an increase in cyclobutane pyrimidine dimers following 40 days of daily irradiation with a UV dose of 70 J/m2 (0.14 MED)
• however, no hyperplasia is observed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 50% and 100% of mice develop squamous cell carcinomas at weeks 11 and 15, respectively, whereas wild-type mice develop similar percentages at weeks 16 and 20, respectively, following a daily dose of 250 J/m2
• yields of squamous cell carcinomas larger than 1mm and 2mm are increased following a daily dose of 250 J/m2
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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