All Phenotypes Crmp1<tm1.1Swl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Crmp1^tm1.1Swl
targeted mutation 1.1, Shu-Wha Lin
MGI:3707322

Summary

2 genotypes

Allelic Composition	Crmp1^tm1.1Swl/Crmp1^tm1.1Swl
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Crmp1^tm1.1Swl mutation (0 available); any Crmp1 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

• MAP2+ CA1 pyramidal cells are shrunken but not due to abnormal Tau expression

• mice have fewer growth cones in the dendritic layer of CA1

• however, pyramidale and stratum oriens layers are normal

• dendrites and dendritic spine are poorly formed

• however, axon formation is normal

abnormal long-term potentiation ( J:120105 )

• mice are impaired in long term potentiation induction and maintenance

• however, paired pulse facilitation of field excitatory postsynaptic potentials are normal

behavior/neurological

abnormal spatial learning ( J:120105 )

• longer mean daily escape latencies even after training

• however, no visual or spontaneous locomotor activity deficits are observed

• mice spend less time in target quadrants and more time in non-target quadrants than control mice

Allelic Composition	Crmp1^tm1.1Swl/Crmp1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6