All Phenotypes Ift57<tm2Dwni> MGI Mouse

embryonic lethality during organogenesis, incomplete penetrance ( J:119664 )

• most embryos die between E9.5 and E10.5 however, Mendelian ratios are found at E9.5 embryonic lethality during organogenesis [MP:0006207] most embryos die between E9.5 and E10.5 however, Mendelian ratios are found at E9.5

absent embryonic cilia ( J:119664 )

• at E8.0, monocilia are absent from the node

• however, node gross morphology is normal

abnormal direction of embryo turning ( J:119664 )

• embryonic turning is random with 11 of 40 embryos turning leftwards, 11 of 40 turning rightwards and the remaining 18 so severely distorted that turning direction could not be assessed

delayed embryo turning ( J:119664 )

• variable severity of delay present at E9.5

failure of initiation of embryo turning ( J:119664 )

• in severe cases, mice fail to initiate turning by E9.5

abnormal left-right axis patterning ( J:119664 )

• as shown by bilateral expression of left markers, left-right axis patterning is disrupted

embryonic growth retardation ( J:119664 )

• at E9.5 embryonic growth is retarded

abnormal neural tube morphology ( J:119664 )

• ventral cell specification of the neural tube is lost

absent floor plate ( J:119664 )

• expression analysis at E9.5 indicates absence of the floor plate

incomplete rostral neuropore closure ( J:119664 )

• at E9.5 mice have an opened brain

open neural tube ( J:119664 )

• at E9.5 brain closure and neural tube closure are variable but never complete

abnormal neural tube morphology ( J:119664 )

• ventral cell specification of the neural tube is lost

absent floor plate ( J:119664 )

• expression analysis at E9.5 indicates absence of the floor plate

incomplete rostral neuropore closure ( J:119664 )

• at E9.5 mice have an opened brain

open neural tube ( J:119664 )

• at E9.5 brain closure and neural tube closure are variable but never complete

abnormal cranial flexure morphology ( J:119664 )

• at E9.5 there is often an abnormal curvature of the floor of the cranial flexure

exencephaly ( J:119664 )

• at E13.5 in a single surviving embryo the region above the presumed midbrain is open

abnormal spinal cord morphology ( J:119664 )

• at E9.5 the spinal cord has kinks and displays uneven closure

abnormal direction of heart looping ( J:119664 )

• cardiac looping sidedness is sometimes inverted

pericardial edema ( J:119664 )

• pericardial edema of varying sizes is observed

abnormal maxilla morphology ( J:119664 )

• at E13.5 in a single surviving embryo the maxillary processes fail to fuse and are reduced in length

abnormal maxilla morphology ( J:119664 )

• at E13.5 in a single surviving embryo the maxillary processes fail to fuse and are reduced in length

polydactyly ( J:119664 )

• at E13.5 in a single surviving embryo, both the fore- and hindlimbs exhibit polydactyly