Phenotypes associated with this allele

• Allele Symbol: Pdcd4^tm1Yhcn
• Allele Name: targeted mutation 1, Youhai H Chen
• Allele ID: MGI:3707444
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pdcd4^tm1Yhcn/Pdcd4^tm1Yhcn	B6.129S6-Pdcd4^tm1Yhcn	MGI:3709490

Genotype
MGI:3709490

hm1

• Allelic Composition: Pdcd4^tm1Yhcn/Pdcd4^tm1Yhcn
• Genetic Background: B6.129S6-Pdcd4^tm1Yhcn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:120583 )

• 86% of mice die by 106 weeks of age

• mean life expectancy is reduced to 101 weeks compared to 115 to 150 weeks in C57BL/6 mice

neoplasm

increased B cell derived lymphoma incidence ( J:120583 )

• at autopsy mice have severe disseminated, primarily B cell lymphomas in the lymph nodes and spleen, and frequent metastasis to the liver and kidney

• B cell lymphomas have diffuse, but not follicular, patterns and are clonally derived

• however, no other types of tumors were found

preneoplasia ( J:120583 )

• at approximately 80 weeks mice develop abdominal masses

immune system

abnormal cytokine secretion ( J:120583 )

• significant increased in the secretion of IL-4, OL-10, and IFNG

decreased susceptibility to autoimmune diabetes ( J:120583 )

• reduction in the incidence of type 1 diabetes induced by toxin STZ to 5% compared to 59% in control mice

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:120583 )

• experimental allergic encephalomyelitis (EAE) severity is significantly reduced and mortality is reduced to 14% compared to 24% in control mice

renal/urinary system

kidney cyst ( J:120583 )

• 50% of mice have multi-organ cysts involving the kidney, ovary and prostate compared to 14% of control mice

reproductive system

prostate gland cyst ( J:120583 )

♂ • 50% of mice have multi-organ cysts involving the kidney, ovary and prostate compared to 14% of control mice

ovary cyst ( J:120583 )

♀ • 50% of mice have multi-organ cysts involving the kidney, ovary and prostate compared to 14% of control mice

endocrine/exocrine glands

prostate gland cyst ( J:120583 )

♂ • 50% of mice have multi-organ cysts involving the kidney, ovary and prostate compared to 14% of control mice

ovary cyst ( J:120583 )

♀ • 50% of mice have multi-organ cysts involving the kidney, ovary and prostate compared to 14% of control mice

growth/size/body

prostate gland cyst ( J:120583 )

♂ • 50% of mice have multi-organ cysts involving the kidney, ovary and prostate compared to 14% of control mice

ovary cyst ( J:120583 )

♀ • 50% of mice have multi-organ cysts involving the kidney, ovary and prostate compared to 14% of control mice

kidney cyst ( J:120583 )

• 50% of mice have multi-organ cysts involving the kidney, ovary and prostate compared to 14% of control mice