All Phenotypes Mesp2<tm10Ysa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mesp2^tm10Ysa
targeted mutation 10, Yumiko Saga
MGI:3707537

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mesp2^tm10Ysa/Mesp2^tm10Ysa	involves: C57BL/6 * CBA * ICR	MGI:3709542
ht2	Mesp2^tm10Ysa/Mesp2^tm11Ysa	involves: C57BL/6 * CBA * ICR	MGI:3709551
cx3	Mesp2^tm1Ysa/Mesp2^tm10Ysa Gt(ROSA)26Sor/?	involves: 129 * C57BL/6 * CBA	MGI:3709491
cx4	Mesp1/Mesp2^tm1Ysa/Mesp1⁺ Mesp1/Mesp2^tm1Ysa/Mesp2^tm10Ysa	involves: C57BL/6 * CBA * ICR	MGI:3709550

Allelic Composition	Mesp2^tm10Ysa/Mesp2^tm10Ysa
Genetic Background	involves: C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp2^tm10Ysa mutation (1 available); any Mesp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal rib morphology ( J:119678 )

abnormal vertebrae morphology ( J:119678 )

abnormal thoracic vertebrae morphology ( J:119678 )

abnormal cervical vertebrae morphology ( J:119678 )

abnormal vertebrae development ( J:119678 )

• at E17.5, mice have skeletal defects in the anterior region of the vertebra along the anterior posterior axis

• defects are less severe than in Mesp2^tm11Ysa homozygotes

Allelic Composition	Mesp2^tm10Ysa/Mesp2^tm11Ysa
Genetic Background	involves: C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp2^tm10Ysa mutation (1 available); any Mesp2 mutation (30 available)
Mesp2^tm11Ysa mutation (0 available); any Mesp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal vertebrae morphology ( J:119678 )

• vertebral defects extend to the lumbar level in the most posterior vertebra region

fusion of vertebral arches ( J:119678 )

Allelic Composition	Mesp2^tm1Ysa/Mesp2^tm10Ysa Gt(ROSA)26Sor/?
Genetic Background	involves: 129 * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor mutation (17 available); any Gt(ROSA)26Sor mutation (993 available)
Mesp2^tm10Ysa mutation (1 available); any Mesp2 mutation (30 available)
Mesp2^tm1Ysa mutation (0 available); any Mesp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

failure of somite differentiation ( J:120635 )

• epithelial somites do not form and the entire somatic mesoderm is caudalized

• however, dermamyotome and sclerotome differentiation is unaffected

Allelic Composition	Mesp1/Mesp2^tm1Ysa/Mesp1⁺ Mesp1/Mesp2^tm1Ysa/Mesp2^tm10Ysa
Genetic Background	involves: C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mesp1/Mesp2^tm1Ysa mutation (0 available); any Mesp2 mutation (30 available)
Mesp1/Mesp2^tm1Ysa mutation (2 available); any Mesp1 mutation (18 available)
Mesp2^tm10Ysa mutation (1 available); any Mesp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body length ( J:119678 )

• shortening of the trunk region

skeleton

abnormal vertebrae morphology ( J:119678 )

• severe truncation of the vertebra

fusion of vertebral arches ( J:119678 )

• severe fusion

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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