Phenotypes associated with this allele

• Allele Symbol: Ikbke^tm1Tman
• Allele Name: targeted mutation 1, Tom Maniatis
• Allele ID: MGI:3707541
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ikbke^tm1Tman/Ikbke^tm1Tman	B6.Cg-Ikbke^tm1Tman	MGI:3707550

Genotype
MGI:3707550

hm1

• Allelic Composition: Ikbke^tm1Tman/Ikbke^tm1Tman
• Genetic Background: B6.Cg-Ikbke^tm1Tman

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

lung inflammation ( J:119791 )

• 7 days post infection, mutant lungs display inflammatory infiltrate consisting of lymphocytes, macrophages, and neutrophils

increased susceptibility to Orthomyxoviridae infection ( J:119791 )

• while at inoculations of >7 x10³ pfu, mutant and control mice show 100% mortality, mutants show greater susceptibility to infection by influenza at lower titers than control mice

• in infected primary mouse embryonic fibroblasts, rates of virus replication are similar to wild-type, while the titer continues to increase

• 7 days post-infection, lungs of mutants show increased immunopathology compared to wild-type

growth/size/body

weight loss ( J:119791 )

• after inoculation with 700 pfu, both mutants and controls show a drop of >10% body weight, but mutants continue to lose weight to below 80% of their original body mass before mortality, whereas control mice do not

respiratory system

lung inflammation ( J:119791 )

• 7 days post infection, mutant lungs display inflammatory infiltrate consisting of lymphocytes, macrophages, and neutrophils

cellular

abnormal fibroblast physiology ( J:119791 )

• in mutant fibroblasts, about 30% of IFN-stimulated genes (ISGs) are poorly induced by IFNgamma compared to induction in wild-type fibroblasts