Phenotypes associated with this allele

• Allele Symbol: Ptpn12^tm1Mtr
• Allele Name: targeted mutation 1, Michel L Tremblay
• Allele ID: MGI:3707593
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptpn12^tm1Mtr/Ptpn12^tm1Mtr	involves: 129S4/SvJae * BALB/c	MGI:3708005

Genotype
MGI:3708005

hm1

• Allelic Composition: Ptpn12^tm1Mtr/Ptpn12^tm1Mtr
• Genetic Background: involves: 129S4/SvJae * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:119668 )

• embryos die between E9.5 and E12.5

embryo

abnormal vitelline vasculature morphology ( J:119668 )

• at E9.5, the endothelial cells in the vascular network of the yolk sac are disorganized, fewer endothelial cells are present, branching is decreased and the vessels present are of larger caliber than those in wild-types

• at E10.0, the yolk sac has a 49% to 69%, reduction in CD31+ endothelial cells

• however, normal numbers of erythrocytes and erythrocyte precursors, monocytes, macrocytes and lymphocytes are present

abnormal embryo development ( J:119668 )

• at E9.5 tissues degenerate and detached pycnotic cells fill the neural canal

failure of initiation of embryo turning ( J:119668 )

• at E9.5

abnormal rostral-caudal body axis extension ( J:119668 )

• at E8.5 caudal development is delayed

• at E9.5 caudal development is arrested and the caudal region receding at E10.5

embryonic growth retardation ( J:119668 )

• at E9.5

kinked neural tube ( J:119668 )

• at E9.5 most embryos show severely kinked neural tubes

neural tube degeneration ( J:119668 )

• at E9.5 tissues degenerate and detached pycnotic cells fill the neural canal

• at E10.5 the caudal neural tube is degenerate

abnormal septum transversum morphology ( J:119668 )

• at E10.5 degenerating cells are observed in the septum transversum

abnormal somite development ( J:119668 )

• at E10.5 caudal somites are disorganized and degenerate

• however, somites are observed in the cranial region

cardiovascular system

decreased vascular endothelial cell number ( J:119668 )

• the number of endothelial cells in the yolk sac and aorta is decreased

abnormal vascular branching morphogenesis ( J:119668 )

• the branching of vascular network vessels in the yolk sac is reduced

abnormal vitelline vasculature morphology ( J:119668 )

• at E9.5, the endothelial cells in the vascular network of the yolk sac are disorganized, fewer endothelial cells are present, branching is decreased and the vessels present are of larger caliber than those in wild-types

• at E10.0, the yolk sac has a 49% to 69%, reduction in CD31+ endothelial cells

• however, normal numbers of erythrocytes and erythrocyte precursors, monocytes, macrocytes and lymphocytes are present

abnormal heart development ( J:119668 )

• at E9.5 embryos have smaller cardiac regions

liver/biliary system

abnormal liver development ( J:119668 )

• at E9.5 and E10.5 no hepatic albumin mRNA is expressed indicating absence of hepatic precursor cells

• at E10.5 degenerating cells are observed in the septum transversum and no hepatic epithelial cells present

• however, Hnf3a+ endodermal-derived cells are present in the gut, notochord and floor plate

nervous system

kinked neural tube ( J:119668 )

• at E9.5 most embryos show severely kinked neural tubes

neural tube degeneration ( J:119668 )

• at E9.5 tissues degenerate and detached pycnotic cells fill the neural canal

• at E10.5 the caudal neural tube is degenerate

growth/size/body

embryonic growth retardation ( J:119668 )

• at E9.5