All Phenotypes irdc MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

irdc
ICR derived retinal dysfunction cone
MGI:3707707

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	irdc/irdc Gnat1^irdr/Gnat1^irdr	involves: ICR	MGI:3709398

Allelic Composition	irdc/irdc Gnat1^irdr/Gnat1^irdr
Genetic Background	involves: ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnat1^irdr mutation (2 available); any Gnat1 mutation (20 available)
irdc mutation (0 available); any irdc mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal cone electrophysiology ( J:119862 )

• at 1 month of age, photopic flash electroretinographs (ERGs) show an elevated stimulus intensity threshold and a decrease in amplitude of b-waves with the prolongation of implicit time

• at 1 month of age, photopic flicker ERGs are unrecordable

• however, overall structure and retinal layer thickness is normal up to at least 3 months of age

abnormal rod electrophysiology ( J:119862 )

• at 1 month of age, scotopic flash ERGs show a loss of a-waves, an elevated stimulus intensity threshold, and a severe reduction in b-wave amplitudes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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