Phenotypes associated with this allele

• Allele Symbol: Gnat1^irdr
• Allele Name: ICR derived retinal dysfunction rod
• Allele ID: MGI:3707708
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gnat1^irdr/Gnat1^irdr	involves: ICR	MGI:3709400
cx2	irdc/irdc Gnat1^irdr/Gnat1^irdr	involves: ICR	MGI:3709398
cx3	Gnat1^irdr/Gnat1^irdr Gnat2^cpfl3/Gnat2^cpfl3	STOCK Gnat2^cpfl3 Gnat1^irdr/Boc	MGI:6274001

Genotype
MGI:3709400

hm1

• Allelic Composition: Gnat1^irdr/Gnat1^irdr
• Genetic Background: involves: ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal cone electrophysiology ( J:119862 )

• at 1 month of age, scotopic flash electroretinographs (ERGs) show a loss of a-waves an elevated stimulus intensity threshold, and a sever reduction in b-wave amplitudes that is more severe in Ird1 mice

• at 1 month of age, mice have shorter implicit time of b-waves at all recorded intensities than ICR mice

• however, photopic flash ERGs, intensity-response functions, and photopic flicker are normal, and overall structure and retinal layer thickness is normal up to at least 3 months of age

Genotype
MGI:3709398

cx2

• Allelic Composition: irdc/irdc; Gnat1^irdr/Gnat1^irdr
• Genetic Background: involves: ICR

vision/eye

abnormal cone electrophysiology ( J:119862 )

• at 1 month of age, photopic flash electroretinographs (ERGs) show an elevated stimulus intensity threshold and a decrease in amplitude of b-waves with the prolongation of implicit time

• at 1 month of age, photopic flicker ERGs are unrecordable

• however, overall structure and retinal layer thickness is normal up to at least 3 months of age

abnormal rod electrophysiology ( J:119862 )

• at 1 month of age, scotopic flash ERGs show a loss of a-waves, an elevated stimulus intensity threshold, and a severe reduction in b-wave amplitudes

Genotype
MGI:6274001

cx3

• Allelic Composition: Gnat1^irdr/Gnat1^irdr; Gnat2^cpfl3/Gnat2^cpfl3
• Genetic Background: STOCK Gnat2^cpfl3 Gnat1^irdr/Boc

vision/eye

abnormal eye electrophysiology ( J:153749 )

• as early as 3 weeks of age no rod or cone responses are detected in either light or dark adapted electroretinograms, although the retinal structure appears normal

abnormal cone electrophysiology ( J:153749 )

abnormal rod electrophysiology ( J:153749 )