Analysis Tools|
Allele Symbol Allele Name Allele ID |
Sphk1tm1.1Cgh targeted mutation 1, Shaun R Coughlin MGI:3707992 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decrease in in vitro cardiomyocyte viability when exposed to hypoxia and glucose-deprivation for 4 hrs
• however, viability is no different from wild-type cardiomyocytes under normoxic culture conditions and pre-treatment with1uM of shingosine-1-phosphate improves viability
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• accumulation of mature T cells in the thymus without changes in other thymic subsets
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• mice exhibit a reduction in NK cell egression from the peripheral lymph nodes compared with wild-type mice
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• accumulation of mature T cells in the thymus without changes in other thymic subsets
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• blood and lymph B cell counts are significantly lower than controls
• however, the number of B cells in the spleen and lymph node is normal
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• in the spleen and lymph
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• in bone marrow and slightly in the lymph nodes
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• mice treated with polyinosine polycytidylic acid at P3 - 5 display markedly reduced T cell number in blood and lymph
• however, spleen and lymph node T cell numbers are normal
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• undetectable levels of sphingosine-1-phosphate (S1P) in the plasma and lymph
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• accumulation of mature T cells in the thymus without changes in other thymic subsets
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• mice exhibit a reduction in NK cell egression from the peripheral lymph nodes compared with wild-type mice
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• accumulation of mature T cells in the thymus without changes in other thymic subsets
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• decrease in the number of mature B cells in the bone marrow
• however, immature cell numbers are similar to controls
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• blood and lymph B cell counts are significantly lower than controls
• however, the number of B cells in the spleen and lymph node is normal
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• in the spleen and lymph
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• in bone marrow and slightly in the lymph nodes
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• mice treated with polyinosine polycytidylic acid at P3 - 5 display markedly reduced T cell number in blood and lymph
• however, spleen and lymph node T cell numbers are normal
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• accumulation of mature T cells in the thymus without changes in other thymic subsets
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• after ovalbumin and CFA challenge, pIpC-treated mice exhibit bleeding in the draining peripheral lymph nodes and increased permeability to FITC-dextran unlike control mice
• however, pIpC-treated mice do not exhibit spontaneous bleeding into mucosal lymph nodes
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• after ovalbumin and CFA challenge, pIpC-treated mice exhibit bleeding in the draining peripheral lymph nodes and increased permeability to FITC-dextran unlike control mice
• however, pIpC-treated mice do not exhibit spontaneous bleeding into mucosal lymph nodes and transfusion with wild-type platelets reduces vascular leakage of FITC-dextran
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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