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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(tetO-APPSwInd)102Dbo
transgene insertion 102, David R Borchelt
MGI:3708167
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)102Dbo/0 		involves: C3H/HeJ * C57BL/6 * CBA MGI:3709182


Genotype
MGI:3709182
cx1
Allelic
Composition		 Tg(Camk2a-tTA)1Mmay/0
Tg(tetO-APPSwInd)102Dbo/0
Genetic
Background		 involves: C3H/HeJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-tTA)1Mmay mutation (8 available)
Tg(tetO-APPSwInd)102Dbo mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal nervous system physiology ( J:109829 )
• mice produce transgenic APP protein at 10- to 30-fold over endogenous App levels
• suppression of transgene expression in these mice is most sensitive to doxycycline of the four lines tested

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:109829




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory