Analysis Tools
reproductive system
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• at E16.5-18.5 a lower percentage of axial elements than in males are in close alignment
• no homologous chromosome synapses form
• however, some bright Sycp1/Syce1 foci coat axial elements
• double strand breaks form, as detected by H2afx and Brca1 staining, but are not efficiently processed
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• while the axial elements of the majority of spermatocytes align homologously, some show alignment of some or no chromosomes pairs
• homologous chromosomes synapses initiate in small regions but fail to extend
• double strand breaks form, as detected by H2afx and Brca1 staining, but are not efficiently processed
• only approximately 10% of spermatocytes form XY bodies
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• spermatocytes arrest at stage IV and undergo apoptosis
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small ovary
(
J:119809
)
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• ovaries are minute
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• testes weights average 20% of wild-type
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• all mice are infertile when crossed to wild-type
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• all mice are infertile when crossed to wild-type
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endocrine/exocrine glands
small ovary
(
J:119809
)
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• ovaries are minute
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• testes weights average 20% of wild-type
|
cellular
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• at E16.5-18.5 a lower percentage of axial elements than in males are in close alignment
• no homologous chromosome synapses form
• however, some bright Sycp1/Syce1 foci coat axial elements
• double strand breaks form, as detected by H2afx and Brca1 staining, but are not efficiently processed
|
|
|
• while the axial elements of the majority of spermatocytes align homologously, some show alignment of some or no chromosomes pairs
• homologous chromosomes synapses initiate in small regions but fail to extend
• double strand breaks form, as detected by H2afx and Brca1 staining, but are not efficiently processed
• only approximately 10% of spermatocytes form XY bodies
|
|
|
• spermatocytes arrest at stage IV and undergo apoptosis
|
