nervous system
• leptin fails to depolarize POMC+ neurons and increase firing rate unlike in control neurons
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Allele Symbol Allele Name Allele ID |
Tg(Npy-hrGFP)1Lowl transgene insertion 1, Bradford B Lowell MGI:3709190 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• leptin fails to depolarize POMC+ neurons and increase firing rate unlike in control neurons
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• hemizygotes are viable and fertile
• when exposed to UV light, brain tissues show GFP fluorescence in patterns consistent with the endogenous mouse Npy gene
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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