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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Pomc1-hrGFP)1Lowl
transgene insertion 1, Bradford B Lowell
MGI:3709191
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Leprtm1.1Chua/Leprtm1.1Chua
Tg(Pomc1-cre)16Lowl/0
Tg(Pomc1-hrGFP)1Lowl/0 		involves: 129 * FVB MGI:5142226
cn2
 		Agrptm1(cre)Lowl/Agrp+
Leprtm1.1Chua/Leprtm1.1Chua
Tg(Pomc1-hrGFP)1Lowl/0 		involves: 129S6/SvEvTac * FVB/N MGI:5142229
cn3
 		Leprtm1.1Chua/Leprtm1.1Chua
Slc32a1tm2(cre)Lowl/Slc32a1+
Tg(Pomc1-hrGFP)1Lowl/0 		involves: 129S6/SvEvTac * FVB/N MGI:5142225
cn4
 		Agrptm1(cre)Lowl/Agrp+
Slc32a1tm1Lowl/Slc32a1tm1Lowl
Tg(Pomc1-hrGFP)1Lowl/0 		involves: 129S6/SvEvTac * FVB/N MGI:5142231
tg5
 		Tg(Pomc1-hrGFP)1Lowl/0 FVB-Tg(Pomc1-hrGFP)1Lowl MGI:3709259


Genotype
MGI:5142226
cn1
Allelic
Composition		 Leprtm1.1Chua/Leprtm1.1Chua
Tg(Pomc1-cre)16Lowl/0
Tg(Pomc1-hrGFP)1Lowl/0
Genetic
Background		 involves: 129 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm1.1Chua mutation (1 available); any Lepr mutation (123 available)
Tg(Pomc1-cre)16Lowl mutation (1 available)
Tg(Pomc1-hrGFP)1Lowl mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:174691 )
N
• addtion of leptin to neurons reduces the frequency of spontaneous (s)IPSCs in Pomc1 neurons by about 40%, similar to the inhibition observed in control neurons




Genotype
MGI:5142229
cn2
Allelic
Composition		 Agrptm1(cre)Lowl/Agrp+
Leprtm1.1Chua/Leprtm1.1Chua
Tg(Pomc1-hrGFP)1Lowl/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrptm1(cre)Lowl mutation (1 available); any Agrp mutation (17 available)
Leprtm1.1Chua mutation (1 available); any Lepr mutation (123 available)
Tg(Pomc1-hrGFP)1Lowl mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:174691 )
N
• addition of leptin produces similar inhibition of sIPSCs in neurons to that observed in control preparations




Genotype
MGI:5142225
cn3
Allelic
Composition		 Leprtm1.1Chua/Leprtm1.1Chua
Slc32a1tm2(cre)Lowl/Slc32a1+
Tg(Pomc1-hrGFP)1Lowl/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm1.1Chua mutation (1 available); any Lepr mutation (123 available)
Slc32a1tm2(cre)Lowl mutation (2 available); any Slc32a1 mutation (55 available)
Tg(Pomc1-hrGFP)1Lowl mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal inhibitory postsynaptic currents ( J:174691 )
• addition of leptin fails to reduce the frequency of sIPSCs (spontaneous inhibitory postsynaptic currents) in Pomc1 neurons, while in control slices, the frequency is reduced by about 40%




Genotype
MGI:5142231
cn4
Allelic
Composition		 Agrptm1(cre)Lowl/Agrp+
Slc32a1tm1Lowl/Slc32a1tm1Lowl
Tg(Pomc1-hrGFP)1Lowl/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agrptm1(cre)Lowl mutation (1 available); any Agrp mutation (17 available)
Slc32a1tm1Lowl mutation (1 available); any Slc32a1 mutation (55 available)
Tg(Pomc1-hrGFP)1Lowl mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:174691 )
N
• addition of leptin produces similar inhibition of sIPSCs in neurons to that observed in control preparations




Genotype
MGI:3709259
tg5
Allelic
Composition		 Tg(Pomc1-hrGFP)1Lowl/0
Genetic
Background		 FVB-Tg(Pomc1-hrGFP)1Lowl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pomc1-hrGFP)1Lowl mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:120992 )
• hemizygotes are viable and fertile
• when exposed to UV light, brain tissues show GFP fluorescence in patterns consistent with the endogenous mouse Pomc1 gene




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory