Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Pax8-rtTA2S*M2)1Koes transgene insertion 1, Robert Koesters MGI:3709326 |
| Summary |
13 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice treated with 0.5 mg/ml doxycycline for 5 days followed by 0.25 mg/ml doxycycline for 5 days starting at 3 weeks of age do not display abnormalities in calcium or phosphate homeostasis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice treated with Dox at P28 for 2 weeks and analyzed at 41-42 weeks of age show slow development of kidney cysts
• mice treated with Dox at P0 and analyzed at P14 show a modest kidney phenotype, with a few cysts
• however, blood urea nitrogen levels are normal in Dox treated mice
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 show a modest kidney phenotype, with mild tubule dilatations
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• mice treated with Dox at P28 for 2 weeks and analyzed at 41-42 weeks of age show slow development of kidney cysts
• mice treated with Dox at P0 and analyzed at P14 show a modest kidney phenotype, with a few cysts
• however, blood urea nitrogen levels are normal in Dox treated mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following exposure to doxycycline in utero, mice die 3 to 4 weeks after birth with giant polycystic kidneys
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• following exposure to doxycycline in utero, newborn mice exhibit fulminant cysts and giant polycystic kidneys form by 3 to 4 weeks of age
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• following exposure to doxycycline in utero, new born mice exhibit hyperplasia of the proximal and distal tubules and collecting duct epithelium
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• following exposure to doxycycline in utero, newborn mice exhibit fulminant cysts and giant polycystic kidneys form by 3 to 4 weeks of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autosomal recessive polycystic kidney disease | DOID:0110861 | J:140925 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice treated with doxycycline (Dox) at P0 and analyzed at P14 do not form kidney cysts
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 show development of kidney cysts, with increased kidney weight/body weight ratio and more numerous and larger cysts than single conditional Tulp3 homozygotes
• however, mice treated with Dox at P28 and analyzed at 18 weeks of age show amelioration of the cystic phenotype with no difference in cystic index
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 show increased kidney weight/body weight ratio due to cysts
• mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks of age show a modest elevation of kidney weight/body weight ratio
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• mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks of age show larger tubule dilations
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• mice treated with Dox at P0 show elevated blood urea nitrogen levels
• however, mice treated with Dox at P28 and analyzed at 18 weeks of age show no differences in blood urea nitrogen levels
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 show development of kidney cysts, with increased kidney weight/body weight ratio and more numerous and larger cysts than single conditional Tulp3 homozygotes
• however, mice treated with Dox at P28 and analyzed at 18 weeks of age show amelioration of the cystic phenotype with no difference in cystic index
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 show increased kidney weight/body weight ratio due to cysts
• mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks of age show a modest elevation of kidney weight/body weight ratio
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice treated with Dox at P0 and analyzed at P14 exhibit a severe cystic phenotype
• mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks develop severe cystic kidneys
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit increased kidney weight/body weight ratio due to cysts
• mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks exhibit increased kidney weight/body weight ratio due to cysts
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• mice treated with Dox at P0 show increased blood urea nitrogen levels at P14
• mice treated with Dox at P28 for 2 weeks show increased blood urea nitrogen levels at 18 weeks of age
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• mice treated with Dox at P0 and analyzed at P14 exhibit a severe cystic phenotype
• mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks develop severe cystic kidneys
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit increased kidney weight/body weight ratio due to cysts
• mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks exhibit increased kidney weight/body weight ratio due to cysts
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit a severe cystic phenotype
• mice treated with Dox a P28 for 2 weeks and analyzed at 18 weeks show an intermediate cystic phenotype, with cystic index lower than conditional Pkd1 homozygotes but higher than in double Tulp3 and Pkd1 homozygotes
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit increased kidney weight/body weight ratio due to cysts
• mice treated with Dox a P28 for 2 weeks and analyzed at 18 weeks show an intermediate kidney weight/body weight ratio, with lower ratio than conditional Pkd1 homozygotes but higher ratio than in double Tulp3 and Pkd1 homozygotes
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• mice treated with Dox at P0 show increased blood urea nitrogen levels at P14
• mice treated with Dox a P28 for 2 weeks and analyzed at 18 weeks show an intermediate level of blood urea nitrogen, with lower level than conditional Pkd1 homozygotes but higher level than in double Tulp3 and Pkd1 homozygotes
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit a severe cystic phenotype
• mice treated with Dox a P28 for 2 weeks and analyzed at 18 weeks show an intermediate cystic phenotype, with cystic index lower than conditional Pkd1 homozygotes but higher than in double Tulp3 and Pkd1 homozygotes
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit increased kidney weight/body weight ratio due to cysts
• mice treated with Dox a P28 for 2 weeks and analyzed at 18 weeks show an intermediate kidney weight/body weight ratio, with lower ratio than conditional Pkd1 homozygotes but higher ratio than in double Tulp3 and Pkd1 homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit a severe cystic phenotype
• however, mice treated with Dox at P28 and analyzed at 18 weeks of age show amelioration of the cystic phenotype with no difference in cystic index
|
|
• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit increased kidney weight/body weight ratio due to cysts
• however, mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks of age show no differences in kidney weight/body weight ratio
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• mice treated with Dox at P0 show increased blood urea nitrogen levels at P14
• however, mice treated with Dox at P28 and analyzed at 18 weeks of age show no differences in blood urea nitrogen levels
|
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• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit a severe cystic phenotype
• however, mice treated with Dox at P28 and analyzed at 18 weeks of age show amelioration of the cystic phenotype with no difference in cystic index
|
|
• mice treated with doxycycline (Dox) at P0 and analyzed at P14 exhibit increased kidney weight/body weight ratio due to cysts
• however, mice treated with Dox at P28 for 2 weeks and analyzed at 18 weeks of age show no differences in kidney weight/body weight ratio
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following ischemia/reperfusion injury, doxycycline-treated mice exhibit a misorganized, multi-layered, hyperproliferative epithelium and impaired recovery of renal function
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• following ischemia/reperfusion injury, doxycycline-treated mice exhibit a misorganized, multi-layered, hyperproliferative epithelium and impaired recovery of renal function
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• following ischemia/reperfusion injury, doxycycline-treated mice exhibit a misorganized, multi-layered, hyperproliferative epithelium and impaired recovery of renal function
• dividing cells of doxycycline-treated mice during kidney repair show a high shift toward mitotic spindle angles perpendicular to the epithelial plane
• however, doxycline-treated mice exhibit normal kidney histology and function under basal conditions
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• doxycycline-treated mice (six cycles of discontinuous treatment) show distinct renal fibrosis
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• serum creatinine, blood urea nitrogen and urinary albumin-to-creatinine ratio measurements are not altered
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• serum creatinine, blood urea nitrogen and urinary albumin-to-creatinine ratio measurements are not altered
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following induction with doxycycline, mice develop glomerular cysts
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• following induction with doxycycline, mice develop multiple renal cysts in all renal tubular compartments
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• following induction with doxycycline
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• 3 to 4 months following induction with doxycycline
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• following induction with doxycycline, mice develop renal adenomas
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• following induction with doxycycline
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• following induction with doxycycline, mice develop glomerular cysts
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• following induction with doxycycline, mice develop multiple renal cysts in all renal tubular compartments
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| cystic kidney disease | DOID:2975 | J:140925 | ||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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