Phenotypes associated with this allele

• Allele Symbol: Spint1^{Gt(OST380474)Lex}
• Allele Name: gene trap OST380474, Lexicon Genetics
• Allele ID: MGI:3709554
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spint1^Gt(OST380474)Lex/Spint1^Gt(OST380474)Lex	involves: 129S5/SvEvBrd	MGI:3810330

Genotype
MGI:3810330

hm1

• Allelic Composition: Spint1^{Gt(OST380474)Lex}/Spint1^{Gt(OST380474)Lex}
• Genetic Background: involves: 129S5/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:118798 )

• mice die between E10.5 and E11.5 due to defects in the placental labyrinth architecture

embryo

embryo phenotype ( J:118798 )

N • despite defects in placenta labyrinth vasculature, mice exhibit normal embryonic and yolk sac vasculature

abnormal placenta labyrinth morphology ( J:118798 )

• mice exhibit patchy and discontinuous collagen IV and laminin staining of the placenta labyrinth basement membrane

• the basement membrane of the placenta labyrinth is disorganized

abnormal placental labyrinth vasculature morphology ( J:118798 )

• mice exhibit defects in placental labyrinth vascularization consisting of a lack of fetal blood vessels and reduced trophoblast layer

abnormal trophoblast layer morphology ( J:118798 )

• the trophoblast layer is compact due to decreased branching morphogenesis comapred to in wild-type mice

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:118798 )

• mice exhibit defects in placental labyrinth vascularization consisting of a lack of fetal blood vessels and reduced trophoblast layer

cellular

abnormal basement membrane morphology ( J:118798 )

• mice exhibit patchy and discontinuous collagen IV and laminin staining of the placenta labyrinth basement membrane

• the basement membrane of the placenta labyrinth is disorganized