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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mir155tm1Rsky
targeted mutation 1, Klaus Rajewsky
MGI:3709846
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mir155tm1Rsky/Mir155tm1Rsky involves: 129 * C57BL/6 MGI:3809684
hm2
 		Mir155tm1Rsky/Mir155tm1Rsky involves: 129/Sv * C57BL/6 MGI:3712188


Genotype
MGI:3809684
hm1
Allelic
Composition		 Mir155tm1Rsky/Mir155tm1Rsky
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir155tm1Rsky mutation (1 available); any Mir155 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:136224 )
• class switching is impaired compared to in wild-type mice

cellular
chromosomal instability ( J:136224 )
• B cells exhibit a 15-fold increase in reciprocal chromosome translocations between Igh and Myc compared to in Aicdatm1HonM heterozygotes

hematopoietic system
abnormal class switch recombination ( J:136224 )
• class switching is impaired compared to in wild-type mice




Genotype
MGI:3712188
hm2
Allelic
Composition		 Mir155tm1Rsky/Mir155tm1Rsky
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir155tm1Rsky mutation (1 available); any Mir155 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased spleen germinal center number ( J:121084 )
• germinal centers are reduced in number in the spleen compared to control and Gt(ROSA)26Sortm1Rsky homozygous mice
decreased spleen germinal center size ( J:121084 )
• germinal centers are smaller in the spleen compared to control and Gt(ROSA)26Sortm1Rsky homozygous mice
abnormal gut-associated lymphoid tissue morphology ( J:121084 )
• both Peyer's patches and mesenteric lymph nodes have a decrease in germinal center B cells
abnormal Peyer's patch germinal center morphology ( J:121084 )
• contains less germinal center B Cells
abnormal humoral immune response ( J:121084 )
• antibody response to NP-CGG is reduced to about one fifth
• however, splenic germinal center B cell numbers are comparable to those in a normal response
decreased interferon-gamma secretion ( J:121084 )
• under in vitro conditions that promote does not any differentiation pathway, interferon gamma production is reduced
increased interleukin-10 secretion ( J:121084 )
• under in vitro conditions that promote does not any differentiation pathway IL-10 production is increased
decreased interleukin-4 secretion ( J:121084 )
• under in vitro conditions that promote does not any differentiation pathway, IL-4 production is reduced
decreased tumor necrosis factor secretion ( J:121084 )
• following BCR activation, B cells produce less TNF

hematopoietic system
decreased spleen germinal center number ( J:121084 )
• germinal centers are reduced in number in the spleen compared to control and Gt(ROSA)26Sortm1Rsky homozygous mice
decreased spleen germinal center size ( J:121084 )
• germinal centers are smaller in the spleen compared to control and Gt(ROSA)26Sortm1Rsky homozygous mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory