Analysis Tools
immune system
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• no gross defects in myeloid or lymphoid development are observed in mutants
• all analyses are done on F2 mixed background consisting of 129S7/SvEvBrd (50%) and C57BL/6-Tyrc-Brd (50%)
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• many mice develop enteric inflammation
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• tetanus toxin fragment C-immunized mice show impaired B cell responses
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• tetanus toxin fragment C-immunized mice produce reduced amounts of switched antigen-specific antibodies
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• tetanus toxin fragment C-immunized (TetC) mice produce reduced amounts of IgM compared to controls
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• splenocytes from TetC-immunized mice do not produce significant amounts of Il-2 and Ifng upon restimulation compared to immunized wild-type splenocytes
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• significant numbers of leukocytes are found in bronchoalveolar lavage fluid in mutants
• no increase in inflammatory cells is seen in lung interstitium
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respiratory system
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• significant numbers of leukocytes are found in bronchoalveolar lavage fluid in mutants
• no increase in inflammatory cells is seen in lung interstitium
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• at 320-350 days of age, mice develop lung pathology
• 56% show extensive airway remodeling
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• increased bronchiolar subepithelial collagen deposition and increased cell mass of sub-bronchiolar myofibroblasts is observed relative to controls at >350 days
• significant increases in ratio of collagen thickness/bronchiolar diameter and smooth muscle cell area/bronchiolar diameter can be measured compared to controls
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digestive/alimentary system
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• many mice develop enteric inflammation
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hematopoietic system
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• tetanus toxin fragment C-immunized mice show impaired B cell responses
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• tetanus toxin fragment C-immunized mice produce reduced amounts of switched antigen-specific antibodies
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• tetanus toxin fragment C-immunized (TetC) mice produce reduced amounts of IgM compared to controls
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