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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ghrltm1Mko
targeted mutation 1, Masayasu Kojima
MGI:3709886
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ghrltm1Mko/Ghrltm1Mko B6.Cg-Ghrltm1Mko MGI:3711322


Genotype
MGI:3711322
hm1
Allelic
Composition
Ghrltm1Mko/Ghrltm1Mko
Genetic
Background
B6.Cg-Ghrltm1Mko
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ghrltm1Mko mutation (0 available); any Ghrl mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• no differences in size or density of pancreatic islets are seen compared to wild-type
• glucose-induced insulin release is significantly higher than in wild-type mice, while basal insulin release levels are not different from wild-type; amount released/islet is increased in response to glucose compared to wild-type

homeostasis/metabolism
N
• 8-week old mice fed regular chow show no differences in body weight, total 24-hour food intake, and serum glucose levels relative to controls
• responses to insulin tolerance tests are not different from wild-type, indicating no differences in insulin sensitivity
• glucose-induced insulin release is significantly higher than in wild-type mice, while basal insulin release levels are not different from wild-type; amount released/islet is increased in response to glucose compared to wild-type
• in glucose tolerance tests, mice show attenuated elevation of blood glucose levels relative to wild-type
• on a high-fat diet, glucose levels do not increase as much as in wild-type in glucose tolerance tests; at 15-20 minutes after injection, levels are similar to control diet group
• when fed a high-fat diet, mice do not show the same moderate increase in glucose level as wild-type mice
• in glucose tolerance tests, mice show attenuated elevation of insulin levels relative to wild-type
• on a high-fat diet, increases in insulin levels are much greater than in wild-type mice; in a glucose tolerance test, insulin levels at 15 minutes are markedly enhancec compared to wild-type
• mice are resistant to glucose intolerance on a high-fat diet





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory