endocrine/exocrine glands
N |
• no differences in size or density of pancreatic islets are seen compared to wild-type
|
• glucose-induced insulin release is significantly higher than in wild-type mice, while basal insulin release levels are not different from wild-type; amount released/islet is increased in response to glucose compared to wild-type
|
homeostasis/metabolism
N |
• 8-week old mice fed regular chow show no differences in body weight, total 24-hour food intake, and serum glucose levels relative to controls
|
• responses to insulin tolerance tests are not different from wild-type, indicating no differences in insulin sensitivity
|
• glucose-induced insulin release is significantly higher than in wild-type mice, while basal insulin release levels are not different from wild-type; amount released/islet is increased in response to glucose compared to wild-type
|
• in glucose tolerance tests, mice show attenuated elevation of blood glucose levels relative to wild-type
• on a high-fat diet, glucose levels do not increase as much as in wild-type in glucose tolerance tests; at 15-20 minutes after injection, levels are similar to control diet group
• when fed a high-fat diet, mice do not show the same moderate increase in glucose level as wild-type mice
|
• in glucose tolerance tests, mice show attenuated elevation of insulin levels relative to wild-type
• on a high-fat diet, increases in insulin levels are much greater than in wild-type mice; in a glucose tolerance test, insulin levels at 15 minutes are markedly enhancec compared to wild-type
|
• mice are resistant to glucose intolerance on a high-fat diet
|