Phenotypes associated with this allele

• Allele Symbol: Mir208a^tm1.1Eno
• Allele Name: targeted mutation 1.1, Eric N Olson
• Allele ID: MGI:3709980
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir208a^tm1.1Eno/Mir208a^tm1.1Eno	involves: C57BL/6	MGI:3711774
cx2	Mir208a^tm1.1Eno/Mir208a^tm1.1Eno Tg(Myh6-Ppp3ca)37Eno/0	involves: C57BL/6 * FVB	MGI:3711839

Genotype
MGI:3711774

hm1

• Allelic Composition: Mir208a^tm1.1Eno/Mir208a^tm1.1Eno
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardium layer morphology ( J:120908 )

• in response to thoracic aortic banding (TAB), mutant animals show almost no cardiomyocyte hypertrophy or fibrosis

abnormal heart left ventricle morphology ( J:120908 )

• left ventricular diameter increases during systole

abnormal cardiovascular system physiology ( J:120908 )

• in mice >6 months of age, cardiac function declines

• in response to TAB, null animals display a blunted hypertrophic response

decreased cardiac muscle contractility ( J:120908 )

• slight reduction in contractility compared to wild-type at 2 months of age

• in response to thoracic aortic banding (TAB), contractility is reduced

muscle

abnormal myocardium layer morphology ( J:120908 )

• in response to thoracic aortic banding (TAB), mutant animals show almost no cardiomyocyte hypertrophy or fibrosis

decreased cardiac muscle contractility ( J:120908 )

• slight reduction in contractility compared to wild-type at 2 months of age

• in response to thoracic aortic banding (TAB), contractility is reduced

abnormal sarcomere morphology ( J:120908 )

• in mice >6 months of age, abnormalities in sarcomere structure are observed

Genotype
MGI:3711839

cx2

• Allelic Composition: Mir208a^tm1.1Eno/Mir208a^tm1.1Eno; Tg(Myh6-Ppp3ca)37Eno/0
• Genetic Background: involves: C57BL/6 * FVB

cardiovascular system

cardiovascular system phenotype ( J:120908 )

N • null mice expressing the transgene do not show cardiomyocyte hypertrophy or fibrosis in with expression of this transgene, in contrast to wild-type transgenic mice