Phenotypes associated with this allele

• Allele Symbol: T^{Tg(MT2A-Myc)137Misu}
• Allele Name: transgene insertion 137, Misao Suzuki
• Allele ID: MGI:3710000
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	T^Tg(MT2A-Myc)137Misu/T^Tg(MT2A-Myc)137Misu	C57BL/6-T^Tg(MT2A-Myc)137Misu	MGI:3710087
ht2	T^Tg(MT2A-Myc)137Misu/T^+	C57BL/6-T^Tg(MT2A-Myc)137Misu	MGI:3710088

Genotype
MGI:3710087

hm1

• Allelic Composition: T^{Tg(MT2A-Myc)137Misu}/T^{Tg(MT2A-Myc)137Misu}
• Genetic Background: C57BL/6-T^{Tg(MT2A-Myc)137Misu}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Embryonic morphologies of +/+ and T^{Tg(MT2A-Myc)137Misu}/T^{Tg(MT2A-Myc)137Misu} at E9.5

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:60706 )

• die shortly after E10.5

growth/size/body

embryonic growth retardation ( J:60706 )

• some embryos are growth retarded

decreased body size ( J:60706 )

• seen in some embryos by E9.5

embryo

incomplete embryo turning ( J:60706 )

• some homozygotes fail to curve the posterior body

embryonic growth retardation ( J:60706 )

• some embryos are growth retarded

abnormal neural tube morphology ( J:60706 )

• some mutants exhibit a kinked neural tube at the 5th-6th somite

abnormal notochord morphology ( J:60706 )

• some mutants exhibit a discontinuous notochord at E9.5

abnormal somite development ( J:60706 )

• reduced number of somite pairs at E9.5

nervous system

abnormal neural tube morphology ( J:60706 )

• some mutants exhibit a kinked neural tube at the 5th-6th somite

cardiovascular system

failure of heart looping ( J:60706 )

• heart is unlooped at E10.5

distended pericardium ( J:60706 )

• pericardial cavity is swollen at E10.5

Genotype
MGI:3710088

ht2

• Allelic Composition: T^{Tg(MT2A-Myc)137Misu}/T⁺
• Genetic Background: C57BL/6-T^{Tg(MT2A-Myc)137Misu}

limbs/digits/tail

kinked tail ( J:60706 )

• most mutants have a kinked or bent tail