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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(MT2A-Myc)#Misu
transgene insertion #, Misao Suzuki
MGI:3710006
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(MT2A-Myc)#Misu/0 C57BL/6-Tg(MT2A-Myc)#Misu MGI:3710016


Genotype
MGI:3710016
tg1
Allelic
Composition		 Tg(MT2A-Myc)#Misu/0
Genetic
Background		 C57BL/6-Tg(MT2A-Myc)#Misu
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal seminiferous tubule morphology ( J:121355 )
• the interstitial tissue is hyperplastic
decreased testis weight ( J:121355 )
• testis weight is on average 1/5 that of controls
azoospermia ( J:121355 )
• no sperm are seen within the seminiferous tubules or the cauda epididymis
arrest of spermatogenesis ( J:121355 )
• male germ cell death occurs about 7 days after birth, and, consequently, spermatogenesis is arrested at the entry into the meiotic prophase
• germ cell death is caused by apoptosis

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:121355 )
• the interstitial tissue is hyperplastic
decreased testis weight ( J:121355 )
• testis weight is on average 1/5 that of controls

cellular
azoospermia ( J:121355 )
• no sperm are seen within the seminiferous tubules or the cauda epididymis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory