Phenotypes associated with this allele

• Allele Symbol: Rasa3^tm1Shiw
• Allele Name: targeted mutation 1, Shintaro Iwashita
• Allele ID: MGI:3710014
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rasa3^tm1Shiw/Rasa3^tm1Shiw	Not Specified	MGI:3711069

Genotype
MGI:3711069

hm1

• Allelic Composition: Rasa3^tm1Shiw/Rasa3^tm1Shiw
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Rasa3^tm1Shiw/Rasa3^tm1Shiw mice exhibit edema and hemorrhaging in the head and trunk

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:120930 )

• no mice are recovered at birth but they are present with defects at E15.5

cardiovascular system

abnormal vascular endothelial cell development ( J:120930 )

• adherens junctions between capillary endothelial cells are less developed

hemorrhage ( J:120930 )

• at E12.5, some mice have brain and/or rump hemorrhaging

• at E13.5, more than 50 embryos dissected had massive subcutaneous and intraperenchymal bleeding

embryo

abnormal embryo development ( J:120930 )

• at E12.5, embryos exhibit edema and hemorrhaging in the head and trunk

homeostasis/metabolism

edema ( J:120930 )

• seen at E12.5