Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^tm2(SS18)Mrc
• Allele Name: targeted mutation 2, Mario R Capecchi
• Allele ID: MGI:3710095
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc Myf6^tm1(cre)Mrc/Myf6^tm1(cre)Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3710996
cn2	Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc Pax7^tm1(cre)Mrc/Pax7^tm1(cre)Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3710998
cn3	Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc Pax3^tm1(cre)Joe/Pax3^tm1(cre)Joe	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3711001
cn4	Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc Hprt1^tm1(CAG-cre)Mnn/Hprt1^tm1(CAG-cre)Mnn	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3711003
cn5	Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc Myf5^tm1(cre)Mrc/Myf5^tm1(cre)Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3711005

Genotype
MGI:3710996

cn1

• Allelic Composition: Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc; Myf6^tm1(cre)Mrc/Myf6^tm1(cre)Mrc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:120967 )

• mice die by 6 months of age

neoplasm

neoplasm ( J:120967 )

N • unlike in other Gt(ROSA)26Sor^tm2(SS18)Mrc homozygously activated mice, no tumors form

muscle

abnormal skeletal muscle morphology ( J:120967 )

• intrafiber vacuolation is present in some muscle fibers

• apoptosis of differentiated skeletal muscle fibers is increased

centrally nucleated skeletal muscle fibers ( J:120967 )

• central nuclei are present in some muscle fibers

myopathy ( J:120967 )

• myopathy is characterized by abnormal wavy fiber and limited rhabdomyolysis

Genotype
MGI:3710998

cn2

• Allelic Composition: Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc; Pax7^tm1(cre)Mrc/Pax7^tm1(cre)Mrc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:120967 )

• no live embryos are recovered

Genotype
MGI:3711001

cn3

• Allelic Composition: Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc; Pax3^tm1(cre)Joe/Pax3^tm1(cre)Joe
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:120967 )

• no embryos are recovered at E13.5 but are present at E10.5

Genotype
MGI:3711003

cn4

• Allelic Composition: Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc; Hprt1^{tm1(CAG-cre)Mnn}/Hprt1^{tm1(CAG-cre)Mnn}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

prenatal lethality, complete penetrance ( J:120967 )

♀ • no pups were recovered

Genotype
MGI:3711005

cn5

• Allelic Composition: Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc; Myf5^tm1(cre)Mrc/Myf5^tm1(cre)Mrc
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

postnatal lethality, incomplete penetrance ( J:120967 )

• about 8% of mice die by 2 months of age

neoplasm

increased tumor incidence ( J:120967 )

• at 3 to 5 months, 18 of 18 surviving mice developed multiple tumors (3 to 5 per mouse) compared to over 100 control mice who did not develop tumors at more than 1 year of age

• however, mice that died prior to 2 months of age did not have tumors and did not die from tumor-related causes

• most tumors are located within the skeletal muscle in the limbs and intercostals regions with some non-skeletal muscle tissues (such as the cerebellum) harboring tumors

• tumors are vascularized, hemorrhagic and cystic spaces are detected in large tumors

increased sarcoma incidence ( J:120967 )

• synovial sarcomas are detected with monophasic (13) outnumbering biphasic (3)

• myxoid and fibrous changes are observed

growth/size/body

decreased body size ( J:120967 )

• about 8% of mice are born small

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
synovial sarcoma		DOID:5485	OMIM:300813	J:120967