Analysis Tools|
Allele Symbol Allele Name Allele ID |
Myf5tm1(cre)Mrc targeted mutation 1, Mario R Capecchi MGI:3710099 |
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| Summary |
15 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• more so than in Pax7tm1.1Thbr/Pax7tm1.1Thbr Myf5tm1(cre)Mrc/Myf5+ mice at day 110
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• postnatal dwarfism in male, but not female, mice
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| N |
• mice exhibit normal muscle histology
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• dwarfism in male and female mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• myogenic differentiation is impaired in vitro and during regeneration even in the presence of exogenous Wnt3a
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• after injury
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• skeletal muscle regeneration is impaired 4 and 6 days after injury with reduced average fiber size and number of regenerating fibers per field of injury and increased apoptosis compared to in similarly treated wild-type mice
• myogenic differentiation during regeneration is inhibited even in the presence of exogenous Wnt3a
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• 90% of pups are viable with a normal life span and normal musculature
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• occasionally
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• reduced costochondral and costosternal regions of ribs
• newborns with normal rib cages but occasional anomalies
• floating ribs occasionally misshapen
• occasional osseous knob-like protrusions
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• occasional fusion of cartillagenous portions of ribs
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 8% to 10% of mice are born small and perform poorly
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• mice are normal at birth but gradually develop weakness and reduced vitality leasing to their death
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• about 8% of mice die by 2 months of age
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• at 3 to 5 months, 18 of 18 surviving mice developed multiple tumors (3 to 5 per mouse) compared to over 100 control mice who did not develop tumors at more than 1 year of age
• however, mice that died prior to 2 months of age did not have tumors and did not die from tumor-related causes
• most tumors are located within the skeletal muscle in the limbs and intercostals regions with some non-skeletal muscle tissues (such as the cerebellum) harboring tumors
• tumors are vascularized, hemorrhagic and cystic spaces are detected in large tumors
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• synovial sarcomas are detected with monophasic (13) outnumbering biphasic (3)
• myxoid and fibrous changes are observed
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• about 8% of mice are born small
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| synovial sarcoma | DOID:5485 |
OMIM:300813 |
J:120967 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• about 8% of mice die by 2 months of age
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• at 3 to 5 months, 18 of 18 surviving mice developed multiple tumors (3 to 5 per mouse) compared to over 100 control mice who did not develop tumors at more than 1 year of age
• however, mice that died prior to 2 months of age did not have tumors and did not die from tumor-related causes
• small and potentially metastatic tumors are detected
• most tumors are located within the skeletal muscle in the limbs and intercostals regions with some non-skeletal muscle tissues (such as the cerebellum) harboring tumors
• tumors are vascularized, hemorrhagic and cystic spaces are detected in large tumors
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• synovial sarcomas are detected with monophasic (13) outnumbering biphasic (3)
• myxoid and fibrous changes are observed
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• myf5+ lineage cells undergo increased apoptosis ate E11.5 and by E15.5 are absent
• however, myf5+ cells near future rib cartilage and skeletal musculogenesis are normal
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• about 8% of mice are born small
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| synovial sarcoma | DOID:5485 |
OMIM:300813 |
J:120967 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• live to 3 months
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• mice are very small
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• pale axillary and cervical brown adipose tissue depots
• however, tissue mass is not altered
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• in the interscapular brown adipose tissue of mice older than 6 months
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• in the interscapular brown adipose tissue of mice older than 6 months
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• whitening in mice older than 6 months with increased size of the tissue, a switch from multilocular to unilocular morphology, and increased lipid content
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• in unstimulated interscapular brown adipose tissue
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• whitening in mice older than 6 months with increased size of the tissue, a switch from multilocular to unilocular morphology, and increased lipid content
• 3 week old mice fed a high-fat diet exhibit loss of normal brown adipocyte morphology unlike wild-type mice
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• in mice older than 6 months
• however, juvenile mice exhibit normal sized brown adipose tissue depots
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• precipitous drop in body temperature following exposure to cold
• however, diet-induced thermogenesis is normal
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• precipitous drop in body temperature following exposure to cold
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• at all ages
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• in unstimulated interscapular brown adipose tissue
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• with poorly organized cristae in unstimulated interscapular brown adipose tissue
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• reduced basal in interscapular brown adipose tissue
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the interscapular brown adipose tissue of mice older than 6 months
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• pale in 3 month old mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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