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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Myf5tm1(cre)Mrc
targeted mutation 1, Mario R Capecchi
MGI:3710099
Summary 15 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3710994
cn2
Myf5tm1(cre)Mrc/Myf5+
Myod1tm1Jae/Myod1tm1Jae
Pax7tm1.1Thbr/Pax7tm1.1Thbr
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:5548074
cn3
Pax7tm1.1Thbr/Pax7tm1.1Thbr
Myf5tm1(cre)Mrc/Myf5+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:5548073
cn4
Lin28btm1Gqda/Lin28btm1Gqda
Myf5tm1(cre)Mrc/Myf5+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5519076
cn5
Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda/Col1a1+
Myf5tm1(cre)Mrc/Myf5+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5519077
cn6
Lin28atm1Gqda/Lin28atm1Gqda
Myf5tm1(cre)Mrc/Myf5+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5519078
cn7
Lin28btm1Gqda/Lin28btm1Gqda
Myf5tm1(cre)Mrc/Myf5+
Tsc1tm1Djk/Tsc1+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5519081
cn8
Bcl9tm1.1Agt/Bcl9tm1.1Agt
Bcl9ltm1.1Agt/Bcl9ltm1.1Agt
Myf5tm1(cre)Mrc/Myf5+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ MGI:4399036
cn9
Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+
Myf5tm1(cre)Mrc/Myf5+
involves: 129S1/Sv * 129X1/SvJ MGI:3783871
cn10
Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sortm1(DTA)Mrc
Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3710995
cn11
Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc
Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3711005
cn12
Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc
Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3711004
cn13
Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+
Myf5tm1(cre)Mrc/Myf5+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5495318
cn14
Prdm16tm1.1Brsp/Prdm16tm1.1Brsp
Myf5tm1(cre)Mrc/Myf5+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:6107172
cn15
Mecomtm1Miku/Mecomtm1Miku
Prdm16tm1.1Brsp/Prdm16tm1.1Brsp
Myf5tm1(cre)Mrc/Myf5+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JCrlj MGI:6107171


Genotype
MGI:3710994
hm1
Allelic
Composition
Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are viable and fertile




Genotype
MGI:5548074
cn2
Allelic
Composition
Myf5tm1(cre)Mrc/Myf5+
Myod1tm1Jae/Myod1tm1Jae
Pax7tm1.1Thbr/Pax7tm1.1Thbr
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)
Myod1tm1Jae mutation (2 available); any Myod1 mutation (23 available)
Pax7tm1.1Thbr mutation (0 available); any Pax7 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• more so than in Pax7tm1.1Thbr/Pax7tm1.1Thbr Myf5tm1(cre)Mrc/Myf5+ mice at day 110




Genotype
MGI:5548073
cn3
Allelic
Composition
Pax7tm1.1Thbr/Pax7tm1.1Thbr
Myf5tm1(cre)Mrc/Myf5+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)
Pax7tm1.1Thbr mutation (0 available); any Pax7 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle




Genotype
MGI:5519076
cn4
Allelic
Composition
Lin28btm1Gqda/Lin28btm1Gqda
Myf5tm1(cre)Mrc/Myf5+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28btm1Gqda mutation (0 available); any Lin28b mutation (23 available)
Myf5tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism

growth/size/body
• postnatal dwarfism in male, but not female, mice

muscle
N
• mice exhibit normal muscle histology




Genotype
MGI:5519077
cn5
Allelic
Composition
Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda/Col1a1+
Myf5tm1(cre)Mrc/Myf5+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm3(tetO-Mirlet7g/Mir21)Gqda mutation (1 available); any Col1a1 mutation (163 available)
Myf5tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• dwarfism in male and female mice




Genotype
MGI:5519078
cn6
Allelic
Composition
Lin28atm1Gqda/Lin28atm1Gqda
Myf5tm1(cre)Mrc/Myf5+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28atm1Gqda mutation (0 available); any Lin28a mutation (76 available)
Myf5tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
N
• mice exhibit normal size




Genotype
MGI:5519081
cn7
Allelic
Composition
Lin28btm1Gqda/Lin28btm1Gqda
Myf5tm1(cre)Mrc/Myf5+
Tsc1tm1Djk/Tsc1+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lin28btm1Gqda mutation (0 available); any Lin28b mutation (23 available)
Myf5tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)
Tsc1tm1Djk mutation (2 available); any Tsc1 mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
N
• male mice exhibit normal growth




Genotype
MGI:4399036
cn8
Allelic
Composition
Bcl9tm1.1Agt/Bcl9tm1.1Agt
Bcl9ltm1.1Agt/Bcl9ltm1.1Agt
Myf5tm1(cre)Mrc/Myf5+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl9ltm1.1Agt mutation (1 available); any Bcl9l mutation (40 available)
Bcl9tm1.1Agt mutation (1 available); any Bcl9 mutation (47 available)
Myf5tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• myogenic differentiation is impaired in vitro and during regeneration even in the presence of exogenous Wnt3a
• skeletal muscle regeneration is impaired 4 and 6 days after injury with reduced average fiber size and number of regenerating fibers per field of injury and increased apoptosis compared to in similarly treated wild-type mice
• myogenic differentiation during regeneration is inhibited even in the presence of exogenous Wnt3a




Genotype
MGI:3783871
cn9
Allelic
Composition
Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+
Myf5tm1(cre)Mrc/Myf5+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Mrc mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Myf5tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• 90% of pups are viable with a normal life span and normal musculature

skeleton
• reduced costochondral and costosternal regions of ribs
• newborns with normal rib cages but occasional anomalies
• floating ribs occasionally misshapen
• occasional osseous knob-like protrusions
• occasional fusion of cartillagenous portions of ribs




Genotype
MGI:3710995
cn10
Allelic
Composition
Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sortm1(DTA)Mrc
Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Mrc mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Myf5tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• 8% to 10% of mice are born small and perform poorly

behavior/neurological
• mice are normal at birth but gradually develop weakness and reduced vitality leasing to their death




Genotype
MGI:3711005
cn11
Allelic
Composition
Gt(ROSA)26Sortm2(SS18)Mrc/Gt(ROSA)26Sortm2(SS18)Mrc
Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(SS18)Mrc mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Myf5tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about 8% of mice die by 2 months of age

neoplasm
• at 3 to 5 months, 18 of 18 surviving mice developed multiple tumors (3 to 5 per mouse) compared to over 100 control mice who did not develop tumors at more than 1 year of age
• however, mice that died prior to 2 months of age did not have tumors and did not die from tumor-related causes
• most tumors are located within the skeletal muscle in the limbs and intercostals regions with some non-skeletal muscle tissues (such as the cerebellum) harboring tumors
• tumors are vascularized, hemorrhagic and cystic spaces are detected in large tumors
• synovial sarcomas are detected with monophasic (13) outnumbering biphasic (3)
• myxoid and fibrous changes are observed

growth/size/body
• about 8% of mice are born small

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
synovial sarcoma DOID:5485 OMIM:300813
J:120967




Genotype
MGI:3711004
cn12
Allelic
Composition
Gt(ROSA)26Sortm3(SS18/EGFP)Mrc/Gt(ROSA)26Sortm3(SS18/EGFP)Mrc
Myf5tm1(cre)Mrc/Myf5tm1(cre)Mrc
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(SS18/EGFP)Mrc mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Myf5tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about 8% of mice die by 2 months of age

neoplasm
• at 3 to 5 months, 18 of 18 surviving mice developed multiple tumors (3 to 5 per mouse) compared to over 100 control mice who did not develop tumors at more than 1 year of age
• however, mice that died prior to 2 months of age did not have tumors and did not die from tumor-related causes
• small and potentially metastatic tumors are detected
• most tumors are located within the skeletal muscle in the limbs and intercostals regions with some non-skeletal muscle tissues (such as the cerebellum) harboring tumors
• tumors are vascularized, hemorrhagic and cystic spaces are detected in large tumors
• synovial sarcomas are detected with monophasic (13) outnumbering biphasic (3)
• myxoid and fibrous changes are observed

muscle
• myf5+ lineage cells undergo increased apoptosis ate E11.5 and by E15.5 are absent
• however, myf5+ cells near future rib cartilage and skeletal musculogenesis are normal

growth/size/body
• about 8% of mice are born small

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
synovial sarcoma DOID:5485 OMIM:300813
J:120967




Genotype
MGI:5495318
cn13
Allelic
Composition
Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc/Gt(ROSA)26Sor+
Myf5tm1(cre)Mrc/Myf5+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(EWSR1/ATF1)Mrc mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Myf5tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• live to 3 months

growth/size/body
• mice are very small

muscle
• severely myopathic




Genotype
MGI:6107172
cn14
Allelic
Composition
Prdm16tm1.1Brsp/Prdm16tm1.1Brsp
Myf5tm1(cre)Mrc/Myf5+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf5tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)
Prdm16tm1.1Brsp mutation (1 available); any Prdm16 mutation (73 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• pale axillary and cervical brown adipose tissue depots
• however, tissue mass is not altered
• in the interscapular brown adipose tissue of mice older than 6 months
• in the interscapular brown adipose tissue of mice older than 6 months
• whitening in mice older than 6 months with increased size of the tissue, a switch from multilocular to unilocular morphology, and increased lipid content
• in unstimulated interscapular brown adipose tissue
• whitening in mice older than 6 months with increased size of the tissue, a switch from multilocular to unilocular morphology, and increased lipid content
• 3 week old mice fed a high-fat diet exhibit loss of normal brown adipocyte morphology unlike wild-type mice
• in mice older than 6 months
• however, juvenile mice exhibit normal sized brown adipose tissue depots
• precipitous drop in body temperature following exposure to cold
• however, diet-induced thermogenesis is normal

homeostasis/metabolism
• precipitous drop in body temperature following exposure to cold

growth/size/body
• at all ages

cellular
• in unstimulated interscapular brown adipose tissue
• with poorly organized cristae in unstimulated interscapular brown adipose tissue
• reduced basal in interscapular brown adipose tissue




Genotype
MGI:6107171
cn15
Allelic
Composition
Mecomtm1Miku/Mecomtm1Miku
Prdm16tm1.1Brsp/Prdm16tm1.1Brsp
Myf5tm1(cre)Mrc/Myf5+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecomtm1Miku mutation (0 available); any Mecom mutation (81 available)
Myf5tm1(cre)Mrc mutation (1 available); any Myf5 mutation (17 available)
Prdm16tm1.1Brsp mutation (1 available); any Prdm16 mutation (73 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• in the interscapular brown adipose tissue of mice older than 6 months
• pale in 3 month old mice





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory