Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Wap-Tsg101)4389Kuw transgene insertion 4389, Kay-Uwe Wagner MGI:3710126 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• Tsg101 transgene expression rescues mammary epithelial cells
• overexpression of Tsg101 supports expansion of secretory alveolar lobules relative to conditional Tsg101 knockouts, and tissue no longer shows mosaic pattern like non Tsg101-transgenics
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• in contrast to cultured transgenic mammary epithelial cells which show susceptibility to toxicity by transgene expression, mammary tissue in lactating transgenic females appears normal when examined at day 16 of pregnancy and day 1 of lactation; mice can nurse and support their litters, similar to wild-type mice
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• in addition to tumors, some females maintaine as parous mice (4/40), develop solid lesions before 18 months of age
• tumor-free females (19) exhibit mammary gland abnormalities, with inflammatory nodules with squamous metaplasia and ectatic ducts found in almost all abnormal glands
• atypical hyperplasia and squamous metaplasia are common lesions in mammary glands
• some mammary glands of wild-type controls exhibit abnormal morphology resembling a mid-pregnant female
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• some females maintained as parous mice for 12-24 months (3/40; 1 female had 3 tumors in thoracic mammary glands) develop palpable mammary tumors, identified as typical adenocarcinomas and on scirrhous carcinoma compared to only 1 palpable mammary tumor in wild-type controls at 20 months of age
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• some females maintained as parous mice for 12-24 months (3/40; 1 female had 3 tumors in thoracic mammary glands) develop palpable mammary tumors, identified as typical adenocarcinomas and on scirrhous carcinoma compared to only 1 palpable mammary tumor in wild-type controls at 20 months of age
|
|
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• in addition to tumors, some females maintaine as parous mice (4/40), develop solid lesions before 18 months of age
• tumor-free females (19) exhibit mammary gland abnormalities, with inflammatory nodules with squamous metaplasia and ectatic ducts found in almost all abnormal glands
• atypical hyperplasia and squamous metaplasia are common lesions in mammary glands
• some mammary glands of wild-type controls exhibit abnormal morphology resembling a mid-pregnant female
|
|
• some females maintained as parous mice for 12-24 months (3/40; 1 female had 3 tumors in thoracic mammary glands) develop palpable mammary tumors, identified as typical adenocarcinomas and on scirrhous carcinoma compared to only 1 palpable mammary tumor in wild-type controls at 20 months of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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