Phenotypes associated with this allele

• Allele Symbol: Del(12Bdkrb2-Bdkrb1)1Mki
• Allele Name: deletion, Chr 12, Masao Kakoki 1
• Allele ID: MGI:3710158
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(12Bdkrb2-Bdkrb1)1Mki/Del(12Bdkrb2-Bdkrb1)1Mki	involves: C57BL/6J	MGI:3790098

Genotype
MGI:3790098

hm1

• Allelic Composition: Del(12Bdkrb2-Bdkrb1)1Mki/Del(12Bdkrb2-Bdkrb1)1Mki
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Histological changes in the postischemic kidneys of wild type, Bdkrb2^tm1Jfh/Bdkrb2^tm1Jfh and MGI:3710159/MGI:3710159 mice

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:121339 )

• increased mortality following renal ischemia/reperfusion procedure (8 of 13) compared to wild-type (0 of 10), sham controls (0 of 10) and Bdkrb2^tm1Jfh homozygotes (1 of 8)

homeostasis/metabolism

increased circulating creatinine level ( J:121339 )

• postischimic mice have increased plasma creatinine compared to wild-type and Bdkrb2^tm1Jfh homozygotes

decreased blood urea nitrogen level ( J:121339 )

• fasting plasma nitrite/nitrate levels are decreased to a greater degree than in Bdkrb2^tm1Jfh homozygotes

increased blood urea nitrogen level ( J:121339 )

• postischimic mice have increased plasma urea nitrogen compared to wild-type and Bdkrb2^tm1Jfh homozygotes

renal/urinary system

abnormal kidney morphology ( J:121339 )

• in the kidney of postischimic mice there is more oxidative nuclear and mitochondrial DNA modification than in wild-type and Bdkrb2^tm1Jfh homozygotes

• apoptosis rates are increased in postischemic mice compared to in wild-type and Bdkrb2^tm1Jfh homozygotes

abnormal proximal convoluted tubule morphology ( J:121339 )

• postischimic mice have more severe histologial changes in renal proximal tubules than in wild-type and Bdkrb2^tm1Jfh homozygotes