Phenotypes associated with this allele

• Allele Symbol: Dlg1^tm1Taki
• Allele Name: targeted mutation 1, Tetsu Akiyama
• Allele ID: MGI:3710242
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dlg1^tm1Taki/Dlg1^tm1Taki	involves: C57BL/6 * CBA	MGI:3710421

Genotype
MGI:3710421

hm1

• Allelic Composition: Dlg1^tm1Taki/Dlg1^tm1Taki
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:121262 )

• embryos die soon after birth

renal/urinary system

abnormal metanephric mesenchyme morphology ( J:121262 )

• at E11.5 and E12.5, Pax2+ metanephric mesenchyme is contracted

hydronephrosis ( J:121262 )

• in 15% of kidneys

• all mice were examined at E18.5 unless otherwise noted

renal hypoplasia ( J:121262 )

• hypoplasia is accompanied by a decrease in relative kidney length

• however, the number of glomeruli is normal and no dysplasia is observed

abnormal ureter morphology ( J:121262 )

• unilateral duplication is observed in 1 mouse

abnormal ureter development ( J:121262 )

• at E12.5, relative ureteric length is decreased

• at E14.5 and E15.5, the Mullerian duct remains connected to the ureter

• at E14.5 and E18.5, ureters retains a common nephric duct and fail to descent to the bladder wall retaining a connection to the Wolffian duct

• however, the residual common nephric duct is surrounded by sparse mesenchyme similar to that surrounding a normal ureter

• common nephric duct length is normal at E11.2

abnormal ureter urothelium morphology ( J:121262 )

• ureteric epithelium has a significantly lower relative proliferative index than in controls

bifid ureter ( J:121262 )

• at E11.5, one of seven mice have bilateral ectopic caudal branching and 38% of ureters have abnormal branching structures

dilated ureter ( J:121262 )

• at E16.5

large ureter ( J:121262 )

• mice have megaureter

• bilateral megaureter is observed in 1 mouse

ureter hypoplasia ( J:121262 )

• ureters exhibit unilateral or bilateral hypoplasia

reproductive system

abnormal reproductive system morphology ( J:121262 )

• gonads are malpositioned in 5 of 8 mice

absent seminal vesicle ( J:121262 )

♂ • at E16.5

ectopic ovary ( J:121262 )

• ovaries are often positioned between the adrenal glands and the kidneys

cryptorchism ( J:121262 )

♂ • testes are often found in the abdominal cavity at irregular positions

abnormal uterus morphology ( J:121262 )

♀ • uteri are malpositioned, separated laterally and end blindly

blind uterus ( J:121262 )

♀ • uteri end blindly

absent vagina ( J:121262 )

♀ • mice have vaginal aplasia

growth/size/body

cleft palate ( J:121262 )

decreased body length ( J:121262 )

• mice are significantly shorter

respiratory system

decreased lung weight ( J:121262 )

craniofacial

cleft palate ( J:121262 )

endocrine/exocrine glands

absent seminal vesicle ( J:121262 )

♂ • at E16.5

ectopic ovary ( J:121262 )

• ovaries are often positioned between the adrenal glands and the kidneys

cryptorchism ( J:121262 )

♂ • testes are often found in the abdominal cavity at irregular positions

digestive/alimentary system

cleft palate ( J:121262 )

abnormal intestine morphology ( J:121262 )

• reduced whole intestine length

embryo

abnormal Mullerian duct morphology ( J:121262 )

• at E13.5 the lower end of the Mullerian duct has not elongated to the bladder wall

• at E14.5, the Mullerian duct remains connected to the ureter and in some cases the common nephric duct

• at E15.5 and E18.5, the Mullerian duct has not fused laterally, are constricted and the lower end does not separate from the ureter

abnormal Wolffian duct morphology ( J:121262 )

• at E14.5 and E18.5, ureters retain a connection to the Wolffian duct