Phenotypes associated with this allele

• Allele Symbol: Slc2a3^tm1Dksr
• Allele Name: targeted mutation 1, Sherin U Devaskar
• Allele ID: MGI:3710246
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc2a3^tm1Dksr/Slc2a3^tm1Dksr	B6.129S4-Slc2a3^tm1Dksr	MGI:5049779
ht2	Slc2a3^tm1Dksr/Slc2a3^+	B6.129S4-Slc2a3^tm1Dksr	MGI:3710409

Genotype
MGI:5049779

hm1

• Allelic Composition: Slc2a3^tm1Dksr/Slc2a3^tm1Dksr
• Genetic Background: B6.129S4-Slc2a3^tm1Dksr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:121238 )

• no mice are recovered

Genotype
MGI:3710409

ht2

• Allelic Composition: Slc2a3^tm1Dksr/Slc2a3⁺
• Genetic Background: B6.129S4-Slc2a3^tm1Dksr

mortality/aging

perinatal lethality, incomplete penetrance ( J:121238 )

• an average of approximately 0.5 pups is lost per litter

• there is a 13% decrease in heterozygotes produced by female heterozygotes compared to male heterozygotes

embryo

abnormal placental transport ( J:121238 )

• at E18.5, there is an approximate 31% decrease in transplacental glucose transport

• however, there is no change in intraplacental glucose transport and there is a compensatory increase in intra- and transplacental system A amino acid transport in both the mice and placenta

reproductive system

decreased litter size ( J:121238 )

• litters of two lines contain 4.97+/-0.17 pups and 4.3+/-0.6 pups compared to 6+/-1.29 pups in wild-type

growth/size/body

growth/size/body region phenotype ( J:121238 )

N • body weight and composition are normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:121238 )

N • glucose and insulin tolerance are normal