Phenotypes associated with this allele

• Allele Symbol: Tbx3^{tm1.1(cre)Vmc}
• Allele Name: targeted mutation 1.1, Vincent M Christoffels
• Allele ID: MGI:3710254
• Summary: 8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbx3^tm1.1(cre)Vmc/Tbx3^tm1.1(cre)Vmc	involves: 129P2/OlaHsd * FVB	MGI:3813724
hm2	Tbx3^tm1.1(cre)Vmc/Tbx3^tm1.1(cre)Vmc	involves: 129P2/OlaHsd * FVB/N * NMRI	MGI:4418055
ht3	Tbx3^tm1.1(cre)Vmc/Tbx3^+	involves: 129P2/OlaHsd * FVB/N * NMRI	MGI:4418057
cx4	Tbx2^tm1.1(cre)Vmc/Tbx2^tm1.1(cre)Vmc Tbx3^tm1.1(cre)Vmc/Tbx3^tm1.1(cre)Vmc	involves: 129P2/OlaHsd	MGI:5314603
cx5	Tbx2^tm1.1(cre)Vmc/Tbx2^tm1.1(cre)Vmc Tbx3^tm1.1(cre)Vmc/Tbx3^tm1.1(cre)Vmc	involves: 129P2/OlaHsd * FVB/N	MGI:4418050
cx6	Tbx2^tm1.1(cre)Vmc/Tbx2^tm1.1(cre)Vmc Tbx3^tm1.1(cre)Vmc/Tbx3^+	involves: 129P2/OlaHsd * FVB/N * NMRI	MGI:4418052
cx7	Tbx2^tm1.1(cre)Vmc/Tbx2^+ Tbx3^tm1.1(cre)Vmc/Tbx3^+	involves: 129P2/OlaHsd * FVB/N * NMRI	MGI:4418053
cx8	Tbx2^tm1.1(cre)Vmc/Tbx2^+ Tbx3^tm1.1(cre)Vmc/Tbx3^tm1.1(cre)Vmc	involves: 129P2/OlaHsd * FVB/N * NMRI	MGI:4418051

Genotype
MGI:3813724

hm1

• Allelic Composition: Tbx3^{tm1.1(cre)Vmc}/Tbx3^{tm1.1(cre)Vmc}
• Genetic Background: involves: 129P2/OlaHsd * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:121230 )

• die between E11.5 and E14.5

cardiovascular system

abnormal sinoatrial node morphology ( J:121230 )

• at E11.5, ectopic expression of atrial genes is seen in the node

decreased sinoatrial node size ( J:121230 )

• at E12.5, average volume of the sinoatrial node is smaller

limbs/digits/tail

abnormal limb morphology ( J:121230 )

• limb malformations

endocrine/exocrine glands

abnormal mammary gland development ( J:121230 )

♀ • fail to induce mammary glands

integument

abnormal mammary gland development ( J:121230 )

♀ • fail to induce mammary glands

muscle

abnormal sinoatrial node morphology ( J:121230 )

• at E11.5, ectopic expression of atrial genes is seen in the node

decreased sinoatrial node size ( J:121230 )

• at E12.5, average volume of the sinoatrial node is smaller

Genotype
MGI:4418055

hm2

• Allelic Composition: Tbx3^{tm1.1(cre)Vmc}/Tbx3^{tm1.1(cre)Vmc}
• Genetic Background: involves: 129P2/OlaHsd * FVB/N * NMRI

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:154920 )

• most animals die around E14.5; occasional survival to E15.5 is observed

craniofacial

abnormal palatal shelf fusion at midline ( J:154920 )

• one embryo that survived to E15.5 diplayed palatal shelves that were fused in the middle region but not anteriorly

cleft secondary palate ( J:154920 )

digestive/alimentary system

abnormal palatal shelf fusion at midline ( J:154920 )

• one embryo that survived to E15.5 diplayed palatal shelves that were fused in the middle region but not anteriorly

cleft secondary palate ( J:154920 )

growth/size/body

abnormal palatal shelf fusion at midline ( J:154920 )

• one embryo that survived to E15.5 diplayed palatal shelves that were fused in the middle region but not anteriorly

cleft secondary palate ( J:154920 )

Genotype
MGI:4418057

ht3

• Allelic Composition: Tbx3^{tm1.1(cre)Vmc}/Tbx3⁺
• Genetic Background: involves: 129P2/OlaHsd * FVB/N * NMRI

normal phenotype

no abnormal phenotype detected ( J:154920 )

• mice are phenotypically normal on this outbred background

Genotype
MGI:5314603

cx4

• Allelic Composition: Tbx2^{tm1.1(cre)Vmc}/Tbx2^{tm1.1(cre)Vmc}; Tbx3^{tm1.1(cre)Vmc}/Tbx3^{tm1.1(cre)Vmc}
• Genetic Background: involves: 129P2/OlaHsd

cardiovascular system

abnormal heart development ( J:181526 )

• mice exhibit abrogation of myocardial patterning of the atrioventricular canal and largely lack the constriction between the left ventricle and atrium

abnormal cardiac jelly morphology ( J:181526 )

• partial loss

absent atrioventricular cushions ( J:181526 )

embryo

embryonic growth retardation ( J:181526 )

• slightly retarded at E9.5

growth/size/body

embryonic growth retardation ( J:181526 )

• slightly retarded at E9.5

Genotype
MGI:4418050

cx5

• Allelic Composition: Tbx2^{tm1.1(cre)Vmc}/Tbx2^{tm1.1(cre)Vmc}; Tbx3^{tm1.1(cre)Vmc}/Tbx3^{tm1.1(cre)Vmc}
• Genetic Background: involves: 129P2/OlaHsd * FVB/N

craniofacial

cleft secondary palate ( J:154920 )

• 11 of 13 embryos show complete cleft palate

digestive/alimentary system

cleft secondary palate ( J:154920 )

• 11 of 13 embryos show complete cleft palate

growth/size/body

cleft secondary palate ( J:154920 )

• 11 of 13 embryos show complete cleft palate

Genotype
MGI:4418052

cx6

• Allelic Composition: Tbx2^{tm1.1(cre)Vmc}/Tbx2^{tm1.1(cre)Vmc}; Tbx3^{tm1.1(cre)Vmc}/Tbx3⁺
• Genetic Background: involves: 129P2/OlaHsd * FVB/N * NMRI

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:154920 )

• the limited number of embryos obtained from intercrosses die at E10.5 due to hemodynamic failure

Genotype
MGI:4418053

cx7

• Allelic Composition: Tbx2^{tm1.1(cre)Vmc}/Tbx2⁺; Tbx3^{tm1.1(cre)Vmc}/Tbx3⁺
• Genetic Background: involves: 129P2/OlaHsd * FVB/N * NMRI

craniofacial

cleft secondary palate ( J:154920 )

• 5 of 13 embryos show complete cleft palate at E18.5

digestive/alimentary system

cleft secondary palate ( J:154920 )

• 5 of 13 embryos show complete cleft palate at E18.5

growth/size/body

cleft secondary palate ( J:154920 )

• 5 of 13 embryos show complete cleft palate at E18.5

Genotype
MGI:4418051

cx8

• Allelic Composition: Tbx2^{tm1.1(cre)Vmc}/Tbx2⁺; Tbx3^{tm1.1(cre)Vmc}/Tbx3^{tm1.1(cre)Vmc}
• Genetic Background: involves: 129P2/OlaHsd * FVB/N * NMRI

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:154920 )

• the limited number of embryos obtained from intercrosses die at E10.5 due to hemodynamic failure