cardiovascular system
• at 6 months of age, the number of ventricular myocytes is increased on average 67.3%
• hearts exhibit an increase in cardiomyocyte DNA synthesis starting at P2, with most cardiomyocytes being mononuclear at P7
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• myocyte cross-sectional areas are slightly reduced and myocyte length is shorter
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• hearts occupy an average of 41% of the chest area compared with 30.5% by the controls, indicating enlargement
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• heart weight to body weight ratio of adults is significantly increased beginning at 6 months of age
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• cardiomyocyte hyperplasia due to an increase in postnatal mitosis
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• mild, but significant, decrease in ejection fraction and fractional shortening in hearts at 8 months of age, but not at 3 months of age
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muscle
• at 6 months of age, the number of ventricular myocytes is increased on average 67.3%
• hearts exhibit an increase in cardiomyocyte DNA synthesis starting at P2, with most cardiomyocytes being mononuclear at P7
|
• myocyte cross-sectional areas are slightly reduced and myocyte length is shorter
|
• mild, but significant, decrease in ejection fraction and fractional shortening in hearts at 8 months of age, but not at 3 months of age
|
growth/size/body
• hearts occupy an average of 41% of the chest area compared with 30.5% by the controls, indicating enlargement
|
• heart weight to body weight ratio of adults is significantly increased beginning at 6 months of age
|
• cardiomyocyte hyperplasia due to an increase in postnatal mitosis
|