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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6-Ccna2)58Djw
transgene insertion 58, Debra J Wolgemuth
MGI:3710498
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Myh6-Ccna2)58Djw/0 involves: C57BL/6 * CBA MGI:3710499


Genotype
MGI:3710499
tg1
Allelic
Composition
Tg(Myh6-Ccna2)58Djw/0
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at 6 months of age, the number of ventricular myocytes is increased on average 67.3%
• hearts exhibit an increase in cardiomyocyte DNA synthesis starting at P2, with most cardiomyocytes being mononuclear at P7
• myocyte cross-sectional areas are slightly reduced and myocyte length is shorter
• hearts occupy an average of 41% of the chest area compared with 30.5% by the controls, indicating enlargement
• heart weight to body weight ratio of adults is significantly increased beginning at 6 months of age
• cardiomyocyte hyperplasia due to an increase in postnatal mitosis
• mild, but significant, decrease in ejection fraction and fractional shortening in hearts at 8 months of age, but not at 3 months of age

muscle
• at 6 months of age, the number of ventricular myocytes is increased on average 67.3%
• hearts exhibit an increase in cardiomyocyte DNA synthesis starting at P2, with most cardiomyocytes being mononuclear at P7
• myocyte cross-sectional areas are slightly reduced and myocyte length is shorter
• mild, but significant, decrease in ejection fraction and fractional shortening in hearts at 8 months of age, but not at 3 months of age

growth/size/body
• hearts occupy an average of 41% of the chest area compared with 30.5% by the controls, indicating enlargement
• heart weight to body weight ratio of adults is significantly increased beginning at 6 months of age
• cardiomyocyte hyperplasia due to an increase in postnatal mitosis





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory