Phenotypes associated with this allele

• Allele Symbol: Tg(Prnp-ITM2B/APP695*40)1Emcg
• Allele Name: transgene insertion 1, Eileen McGowan
• Allele ID: MGI:3710691
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Prnp-ITM2B/APP695*40)1Emcg/0	involves: C3H * C57BL/6	MGI:3710761

Genotype
MGI:3710761

tg1

• Allelic Composition: Tg(Prnp-ITM2B/APP695*40)1Emcg/0
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:101023 )

N • mice do not show Abeta deposits or amyloid plaque formation

homeostasis/metabolism

amyloidosis ( J:101023 )

• Abeta1-40 peptide levels in 3 month old transgenic brains are ~2- to 3-fold higher than levels in Tg(APPSWE)2576Kahs controls (80-120 pm/g vs ~40 pm/g)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:101023