Phenotypes associated with this allele

• Allele Symbol: Jarid2^Gt(ROSA)1Gel
• Allele Name: gene trap 1, Gary E Lyons
• Allele ID: MGI:3710953
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jarid2^Gt(ROSA)1Gel/Jarid2^Gt(ROSA)1Gel	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3710957

Genotype
MGI:3710957

hm1

• Allelic Composition: Jarid2^Gt(ROSA)1Gel/Jarid2^Gt(ROSA)1Gel
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:63359 )

• homozygotes are alive until E18.5, however no live homozygotes among newborns are found, indicating that mutants die around birth

growth/size/body

decreased embryo size ( J:63359 )

embryo

decreased embryo size ( J:63359 )

cardiovascular system

abnormal myocardium layer morphology ( J:63359 )

trabecula carnea hypoplasia ( J:63359 )

• hearts have an abnormally thin trabeculated wall of both ventricular chambers at E16

abnormal myocardium compact layer morphology ( J:63359 )

• mutants exhibit noncompaction of the ventricular wall, so that by E19, the outer compact zone is absent

thin myocardium ( J:63359 )

• thin myocardium is due to a deficiency of the outer compact zone

abnormal coronary vessel morphology ( J:63359 )

• reduction in coronary vessels

double outlet right ventricle ( J:63359 )

• seen at E13 in 14 of 16 homozygotes

dilated heart right atrium ( J:63359 )

abnormal interventricular septum morphology ( J:63359 )

• holes are seen within the ventricular septum

ventricular septal defect ( J:63359 )

• ventricular septal defect at E13

abnormal interventricular groove morphology ( J:63359 )

• mutants exhibit an abnormally deep interventricular groove

abnormal fetal cardiomyocyte proliferation ( J:100923 )

• cell proliferation of cardiomyocytes, but not cardiac fibroblasts, is up-regulated when grown in culture

• the trabecular layer shows an increase in cardiomyocyte proliferation between E12.5 and E16.5

homeostasis/metabolism

edema ( J:63359 )

• hearts at E16 are severely edematous

respiratory system

respiratory failure ( J:63359 )

• lungs of newborns do not inflate resulting in respiratory insufficiency, caused by rib and sternum defects as the lungs and diaphragm appear normal

skeleton

abnormal thoracic cage morphology ( J:63359 )

• ossification of the ribcage is less than that of wild-type

abnormal sternum morphology ( J:63359 )

• sternum fails to fuse and ossify

muscle

abnormal myocardium layer morphology ( J:63359 )

trabecula carnea hypoplasia ( J:63359 )

• hearts have an abnormally thin trabeculated wall of both ventricular chambers at E16

abnormal myocardium compact layer morphology ( J:63359 )

• mutants exhibit noncompaction of the ventricular wall, so that by E19, the outer compact zone is absent

thin myocardium ( J:63359 )

• thin myocardium is due to a deficiency of the outer compact zone

abnormal fetal cardiomyocyte proliferation ( J:100923 )

• cell proliferation of cardiomyocytes, but not cardiac fibroblasts, is up-regulated when grown in culture

• the trabecular layer shows an increase in cardiomyocyte proliferation between E12.5 and E16.5

cellular

abnormal fetal cardiomyocyte proliferation ( J:100923 )

• cell proliferation of cardiomyocytes, but not cardiac fibroblasts, is up-regulated when grown in culture

• the trabecular layer shows an increase in cardiomyocyte proliferation between E12.5 and E16.5