Analysis Tools
mortality/aging
| N |
• expression of the transgene rescues the embryonic lethality observed in Hdh-null animals
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Allele Symbol Allele Name Allele ID |
Tg(YAC353G6)W7Hay transgene insertion W7, Michael Hayden MGI:3710982 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• expression of the transgene rescues the embryonic lethality observed in Hdh-null animals
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• cultured medium spiny neurons are resistant to NMDAR-mediated excitotoxicity compared to wild-type (2.4% apoptotic cells vs 8.6% in wild-type cultures)
• in vivo, quinolinic acid-induced lesion volume is less than that observed in wild-type mice
• medium spiny neurons exposed to staurosporine show less cell death than wild-type neurons in culture (20% apoptotic cells vs 36.8% in wild-type cultures)
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• cultured medium spiny neurons are resistant to NMDAR-mediated excitotoxicity compared to wild-type (2.4% apoptotic cells vs 8.6% in wild-type cultures)
• in vivo, quinolinic acid-induced lesion volume is less than that observed in wild-type mice
• medium spiny neurons exposed to staurosporine show less cell death than wild-type neurons in culture (20% apoptotic cells vs 36.8% in wild-type cultures)
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• cultured medium spiny neurons are resistant to NMDAR-mediated excitotoxicity compared to wild-type (2.4% apoptotic cells vs 8.6% in wild-type cultures)
• in vivo, quinolinic acid-induced lesion volume is less than that observed in wild-type mice
• medium spiny neurons exposed to staurosporine show less cell death than wild-type neurons in culture (20% apoptotic cells vs 36.8% in wild-type cultures)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• transgenic mice show no neuronal loss or neuronal excitoxicity compared to wild-type controls, and in contrast to Tg(YAC128)53Hay mice at 12 months of age
• mice perform as well as wild-type mice in rotarod tests up to and including 10 months, and perform better than Tg(YAC128)53Hay mice at 2, 6, and 8 months
• mice perform better than Tg(YAC128)53Hay mice in open field tests at 2, 6, 8, and 10 months and are indistinguishable from wild-type controls, displaying no hypokinesia
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• increased compared to Tg(YAC128)53Hay mice at 18 months
• brain weight is indistinguishable from wild-type
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• increased volume compared to Tg(YAC128)53Hay mice at 18 months
• striatal volume is indistinguishable from wild-type
• nuclear localization of htt in striatum at 9 months is just detectable, similar to Tg(YAC128)53Hay mice at 2 months of age and this increases with age such that at 12 months,
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/05/2024 MGI 6.24 |
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