Phenotypes associated with this allele

• Allele Symbol: Tg(YAC353G6)W7Hay
• Allele Name: transgene insertion W7, Michael Hayden
• Allele ID: MGI:3710982
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Htt^tm1Hay/Htt^tm1Hay Tg(YAC353G6)W7Hay/0	involves: C57BL/6J * FVB/NJ	MGI:3711010
tg2	Tg(YAC353G6)W7Hay/Tg(YAC353G6)W7Hay	FVB/NJ-Tg(YAC353G6)W7Hay	MGI:3711071
tg3	Tg(YAC353G6)W7Hay/0	FVB/NJ-Tg(YAC353G6)W7Hay	MGI:3711009

Genotype
MGI:3711010

cx1

• Allelic Composition: Htt^tm1Hay/Htt^tm1Hay; Tg(YAC353G6)W7Hay/0
• Genetic Background: involves: C57BL/6J * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:120991 )

N • expression of the transgene rescues the embryonic lethality observed in Hdh-null animals

Genotype
MGI:3711071

tg2

• Allelic Composition: Tg(YAC353G6)W7Hay/Tg(YAC353G6)W7Hay
• Genetic Background: FVB/NJ-Tg(YAC353G6)W7Hay

nervous system

decreased susceptibility to neuronal excitotoxicity ( J:120991 )

• cultured medium spiny neurons are resistant to NMDAR-mediated excitotoxicity compared to wild-type (2.4% apoptotic cells vs 8.6% in wild-type cultures)

• in vivo, quinolinic acid-induced lesion volume is less than that observed in wild-type mice

• medium spiny neurons exposed to staurosporine show less cell death than wild-type neurons in culture (20% apoptotic cells vs 36.8% in wild-type cultures)

homeostasis/metabolism

decreased susceptibility to neuronal excitotoxicity ( J:120991 )

• cultured medium spiny neurons are resistant to NMDAR-mediated excitotoxicity compared to wild-type (2.4% apoptotic cells vs 8.6% in wild-type cultures)

• in vivo, quinolinic acid-induced lesion volume is less than that observed in wild-type mice

• medium spiny neurons exposed to staurosporine show less cell death than wild-type neurons in culture (20% apoptotic cells vs 36.8% in wild-type cultures)

cellular

decreased susceptibility to neuronal excitotoxicity ( J:120991 )

• cultured medium spiny neurons are resistant to NMDAR-mediated excitotoxicity compared to wild-type (2.4% apoptotic cells vs 8.6% in wild-type cultures)

• in vivo, quinolinic acid-induced lesion volume is less than that observed in wild-type mice

• medium spiny neurons exposed to staurosporine show less cell death than wild-type neurons in culture (20% apoptotic cells vs 36.8% in wild-type cultures)

Genotype
MGI:3711009

tg3

• Allelic Composition: Tg(YAC353G6)W7Hay/0
• Genetic Background: FVB/NJ-Tg(YAC353G6)W7Hay

nervous system

nervous system phenotype ( J:120991 )

N • transgenic mice show no neuronal loss or neuronal excitoxicity compared to wild-type controls, and in contrast to Tg(YAC128)53Hay mice at 12 months of age

N • mice perform as well as wild-type mice in rotarod tests up to and including 10 months, and perform better than Tg(YAC128)53Hay mice at 2, 6, and 8 months

N • mice perform better than Tg(YAC128)53Hay mice in open field tests at 2, 6, 8, and 10 months and are indistinguishable from wild-type controls, displaying no hypokinesia

increased brain weight ( J:120991 )

• increased compared to Tg(YAC128)53Hay mice at 18 months

• brain weight is indistinguishable from wild-type

abnormal striatum morphology ( J:120991 )

• increased volume compared to Tg(YAC128)53Hay mice at 18 months

• striatal volume is indistinguishable from wild-type

• nuclear localization of htt in striatum at 9 months is just detectable, similar to Tg(YAC128)53Hay mice at 2 months of age and this increases with age such that at 12 months,