Phenotypes associated with this allele

• Allele Symbol: Ccndbp1^tm1Riet
• Allele Name: targeted mutation 1, Dieter Riethmacher
• Allele ID: MGI:3711012
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccndbp1^tm1Riet/Ccndbp1^tm1Riet	involves: 129P2/OlaHsd * C57BL/6	MGI:3711893

Genotype
MGI:3711893

hm1

• Allelic Composition: Ccndbp1^tm1Riet/Ccndbp1^tm1Riet
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

decreased hepatocyte proliferation ( J:121623 )

• 40-48 hours after partial hepatectomy (PH), mutants show no increase in proliferating cells whereas wild-type livers show maximal DNA synthesis in hepatocytes at this time point

• proliferation is delayed relative to wild-type livers following PH (8% vs 40% of cells in the first 48 hours); from second to sixth day, proliferation is similar

increased hepatocellular carcinoma incidence ( J:121623 )

• males 1-1.5 years of age develop HCAs or HCCs (12.5%)

• 32% of females aged 1.5-2 years develop HCAs or HCCs compared to no tumors in wild-type

increased liver adenoma incidence ( J:121623 )

• 12.5% males 1-1.5 years of age develop hepatocellular carcinomas (HCC) or hepatocellular adenomas (HCA) whereas no wild-type males develop tumors

• 32% of females aged 1.5-2 years develop HCAs or HCCs compared to no tumors in wild-type females

delayed liver regeneration ( J:121623 )

• cell proliferation is delayed in mutant livers resulting in lower liver-to-body mass indices in mutants vs wild-type during the initial 72 hours after partial hepatectomy

neoplasm

increased hepatocellular carcinoma incidence ( J:121623 )

• males 1-1.5 years of age develop HCAs or HCCs (12.5%)

• 32% of females aged 1.5-2 years develop HCAs or HCCs compared to no tumors in wild-type

increased liver adenoma incidence ( J:121623 )

• 12.5% males 1-1.5 years of age develop hepatocellular carcinomas (HCC) or hepatocellular adenomas (HCA) whereas no wild-type males develop tumors

• 32% of females aged 1.5-2 years develop HCAs or HCCs compared to no tumors in wild-type females

embryo

embryo phenotype ( J:121623 )

N • no embryonic phenotypes are detected

behavior/neurological

behavior/neurological phenotype ( J:121623 )

N • mice show no differences in nociception or odor-induced variation in anxiety-like behavior

cellular

decreased hepatocyte proliferation ( J:121623 )

• 40-48 hours after partial hepatectomy (PH), mutants show no increase in proliferating cells whereas wild-type livers show maximal DNA synthesis in hepatocytes at this time point

• proliferation is delayed relative to wild-type livers following PH (8% vs 40% of cells in the first 48 hours); from second to sixth day, proliferation is similar