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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bicc1tm1Emdr
targeted mutation 1, E M de Robertis
MGI:3711021
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bicc1tm1Emdr/Bicc1tm1Emdr B6SJL-Bicc1tm1Emdr MGI:3711062
hm2
 		Bicc1tm1Emdr/Bicc1tm1Emdr B6SJL-Bicc1tm1Emdr/J MGI:4442642


Genotype
MGI:3711062
hm1
Allelic
Composition		 Bicc1tm1Emdr/Bicc1tm1Emdr
Genetic
Background		 B6SJL-Bicc1tm1Emdr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bicc1tm1Emdr mutation (1 available); any Bicc1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:121683 )
• mice survive a for a few weeks after birth

renal/urinary system
polycystic kidney ( J:121683 )
• homozygotes have polycystic kidneys

growth/size/body
polycystic kidney ( J:121683 )
• homozygotes have polycystic kidneys

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
autosomal recessive polycystic kidney disease DOID:0110861 J:121683




Genotype
MGI:4442642
hm2
Allelic
Composition		 Bicc1tm1Emdr/Bicc1tm1Emdr
Genetic
Background		 B6SJL-Bicc1tm1Emdr/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bicc1tm1Emdr mutation (1 available); any Bicc1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:158678 )
• fewer than expected mice are present from E14.5 to birth
perinatal lethality, incomplete penetrance ( J:158678 )
• more than half of mice die perinatally

renal/urinary system
polycystic kidney ( J:158678 )
• as early as E15.5, mice develop cysts with squamous cell lining unlike wild-type mice
• cysts develop from glomeruli, proximal tubules, and the thick ascending limb of the loop of Henle and collecting ducts
enlarged kidney ( J:158678 )
• bilaterally in surviving mice
abnormal nephrogenic zone morphology ( J:158678 )
• mice exhibit a reduction in the nephrogenic zone compared with wild-type mice

liver/biliary system

endocrine/exocrine glands

growth/size/body
biliary cyst ( J:158678 )
pancreas cyst ( J:158678 )
polycystic kidney ( J:158678 )
• as early as E15.5, mice develop cysts with squamous cell lining unlike wild-type mice
• cysts develop from glomeruli, proximal tubules, and the thick ascending limb of the loop of Henle and collecting ducts
enlarged kidney ( J:158678 )
• bilaterally in surviving mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory