All Phenotypes Onecut3<tm1Jqmn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Onecut3^tm1Jqmn
targeted mutation 1, Patrick Jacquemin
MGI:3711023

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Onecut3^tm1Jqmn/Onecut3^tm1Jqmn	involves: 129S1/Sv * 129X1/SvJ * Swiss	MGI:3711875
cx2	Onecut1^tm1Flem/Onecut1^tm1Flem Onecut3^tm1Jqmn/Onecut3^tm1Jqmn	involves: 129S1/Sv * 129X1/SvJ * Swiss	MGI:3711873
cx3	Onecut2^tm1Flem/Onecut2^tm1Flem Onecut3^tm1Jqmn/Onecut3^tm1Jqmn	involves: 129S1/Sv * 129X1/SvJ * Swiss	MGI:3711874

Allelic Composition	Onecut3^tm1Jqmn/Onecut3^tm1Jqmn
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Onecut3^tm1Jqmn mutation (0 available); any Onecut3 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:121610 )

• at E10.5, dorsal and ventral pancreatic buds appear normal; similar results show no difference compared to controls at E14.5

• at E14.5 and E18.5, expression of Neurog3, insulin, and glucagons is comparable to wild-type embryos; endocrine differentiation is normal

• no enteroendocrine defect is observed; pyloric region is normal, Brunner's glands are present in duodenum, and crypt/villus architecture in small intestine is not altered

• enteroendocrine cells differentiate normally

Allelic Composition	Onecut1^tm1Flem/Onecut1^tm1Flem Onecut3^tm1Jqmn/Onecut3^tm1Jqmn
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Onecut1^tm1Flem mutation (0 available); any Onecut1 mutation (12 available)
Onecut3^tm1Jqmn mutation (0 available); any Onecut3 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pancreas morphology ( J:121610 )

• number of Neurog3 expressing cells is reduced relative to controls, similar to Onecut1-null embryos at E14. (~4 cells/section)

abnormal pancreas development ( J:121610 )

pancreas hypoplasia ( J:121610 )

• pancreas hypoplasia is not more severe than in Onecut1 homozygotes

Allelic Composition	Onecut2^tm1Flem/Onecut2^tm1Flem Onecut3^tm1Jqmn/Onecut3^tm1Jqmn
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Onecut2^tm1Flem mutation (0 available); any Onecut2 mutation (21 available)
Onecut3^tm1Jqmn mutation (0 available); any Onecut3 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:121610 )

N	• pancreas organogenesis is normal at all stages in double homozygotes • at E14.5 and E18.5, expression of Neurog3, insulin, and glucagons is comparable to wild-type embryos; endocrine differentiation is normal • enteroendocrine cells differentiate normally

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