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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gli3tm2Blnw
targeted mutation 2, Baolin Wang
MGI:3711052
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gli3tm2Blnw/Gli3tm2Blnw involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N MGI:3711905
ht2
Gli3tm2Blnw/Gli3+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N MGI:3711902
ht3
Gli3tm1Urt/Gli3tm2Blnw involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N MGI:6149471
cx4
Gli3tm2Blnw/Gli3+
Shhtm1Chg/Shhtm1Chg
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N MGI:3711913


Genotype
MGI:3711905
hm1
Allelic
Composition
Gli3tm2Blnw/Gli3tm2Blnw
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3tm2Blnw mutation (0 available); any Gli3 mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die mostly before birth and those that are born die soon after

limbs/digits/tail
• at birth, all of the digits consist of only two very short phalanges with the proximal ones being split with abnormal ossification
• at E16.5, in some mice phalanges lack ossification
• at birth, phalanges are short and proximal ones are split
• extra phalanges element branch from the metatarsals
• at E16.5, mice have 6 to 8 digits that lack identity
• at E16.5
• when present, tibia is shorter

skeleton
• at E16.5, in some mice phalanges lack ossification
• at birth, phalanges are short and proximal ones are split
• extra phalanges element branch from the metatarsals
• at E16.5
• when present, tibia is shorter
• at E16.5, in some mice a ring-shaped ossification forms interdigitally
• at birth ossification between digits is located between the distal phalanges




Genotype
MGI:3711902
ht2
Allelic
Composition
Gli3tm2Blnw/Gli3+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3tm2Blnw mutation (0 available); any Gli3 mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• complete duplication of first digit on each limb
• however, digit identity is normal




Genotype
MGI:6149471
ht3
Allelic
Composition
Gli3tm1Urt/Gli3tm2Blnw
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3tm1Urt mutation (0 available); any Gli3 mutation (81 available)
Gli3tm2Blnw mutation (0 available); any Gli3 mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• mice have extra d1 digit




Genotype
MGI:3711913
cx4
Allelic
Composition
Gli3tm2Blnw/Gli3+
Shhtm1Chg/Shhtm1Chg
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3tm2Blnw mutation (0 available); any Gli3 mutation (81 available)
Shhtm1Chg mutation (2 available); any Shh mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• limb phenotypes are indistinguishable to those seen in Gli3tm2Blnw homozygotes
• digit identity is partially restored with 3 or 4 digits clearly mimicking digits 2 to 4 or 2 to 5 identities
• limb phenotypes are indistinguishable to those seen in Gli3tm2Blnw homozygotes
• limb phenotypes are indistinguishable to those seen in Gli3tm2Blnw homozygotes
• some digits have shortened phalanges
• digit 1 is sometimes duplicated

skeleton
• some digits have shortened phalanges





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory