Phenotypes associated with this allele

• Allele Symbol: Pttg1^tm1Pzg
• Allele Name: targeted mutation 1, Pumin Zhang
• Allele ID: MGI:3711120
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pttg1^tm1Pzg/Pttg1^tm1Pzg	involves: 129S7/SvEvBrd * C57BL/6	MGI:3711672
cx2	Cdc20^Gt(XE368)Byg/Cdc20^Gt(XE368)Byg Pttg1^tm1Pzg/Pttg1^tm1Pzg	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6	MGI:3711666

Genotype
MGI:3711672

hm1

• Allelic Composition: Pttg1^tm1Pzg/Pttg1^tm1Pzg
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:121688 )

N • null mice show no differences from wile-type littermates up to 4 weeks of age

cellular

abnormal cell cycle checkpoint function ( J:121688 )

• cultured MEFs show a significant accumulation of cells in G2/M compared to wild-type cells (41% vs 27%), with concurrent decreases in cells in G1 and S phases

decreased cell proliferation ( J:121688 )

• null mouse embryonic fibroblasts (MEFs) show slower rate of growth relative to heterozygous or wild-type cells

Genotype
MGI:3711666

cx2

• Allelic Composition: Cdc20^Gt(XE368)Byg/Cdc20^Gt(XE368)Byg; Pttg1^tm1Pzg/Pttg1^tm1Pzg
• Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:121535 )

• embryos arrested at the two-cell stage can be isolated at E3.5

• analysis of E1.5 embryos cultured for 18 hours showed that some embryos cannot divide further and arrest at 2 -cell stage

cellular

abnormal chromosome morphology ( J:121535 )

• unlike Cdc20-null embryos, chromosomes do not display metaphase configuration, but are scattered; sister chromatids are separated

• in E1.5 cultured embryos, two-cell embryos stay in metaphase for ~4 hours, then begin to wander away from the metaphase plates