About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Col1a2tm1.1Mcbr
targeted mutation 1.1, Daniel J McBride
MGI:3711122
Summary 6 genotypes


Genotype
MGI:3711190
hm1
Allelic
Composition		 Col1a2tm1.1Mcbr/Col1a2tm1.1Mcbr
Genetic
Background		 B6.129(Cg)-Col1a2tm1.1Mcbr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a2tm1.1Mcbr mutation (0 available); any Col1a2 mutation (120 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:121691 )
• homozygous mice do not survive to weaning age
perinatal lethality, complete penetrance ( J:178743 )
• no homozygous mice are recovered but dead pups are found within 24 hours of birth




Genotype
MGI:5300563
ht2
Allelic
Composition		 Col1a2tm1.1Mcbr/Col1a2+
Genetic
Background		 (A/J x B6.129-Col1a2tm1.1Mcbr)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a2tm1.1Mcbr mutation (0 available); any Col1a2 mutation (120 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:178743 )

skeleton
decreased bone mineral content ( J:178743 )
• decreased bone mineral content
• lower cortical volumetric tissue mineral content
increased bone mineral density ( J:178743 )
• Background Sensitivity: bone mineral density is highest on the mixed A/J and C57BL/6 background compared to F1 crosses to BALB/cByJ, FVB/NJ, or C3H/HeJ
increased volumetric bone mineral density ( J:178743 )
• cortical volumetric tissue mineral density (vTMD) is elevated in the femur
decreased bone trabecula number ( J:178743 )
• fewer and more widely spaced trabeculae
decreased bone strength ( J:178743 )
• femurs are weaker and more brittle

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
osteogenesis imperfecta DOID:12347 OMIM:PS166200
 J:178743




Genotype
MGI:3711191
ht3
Allelic
Composition		 Col1a2tm1.1Mcbr/Col1a2+
Genetic
Background		 B6.129(Cg)-Col1a2tm1.1Mcbr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a2tm1.1Mcbr mutation (0 available); any Col1a2 mutation (120 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:121691 )
• mice show reduced body mass compared to wild-type




Genotype
MGI:5300564
ht4
Allelic
Composition		 Col1a2tm1.1Mcbr/Col1a2+
Genetic
Background		 (BALB/cByJ x B6.129-Col1a2tm1.1Mcbr)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a2tm1.1Mcbr mutation (0 available); any Col1a2 mutation (120 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:178743 )

skeleton
decreased bone mineral content ( J:178743 )
• decreased bone mineral content
• lower cortical volumetric tissue mineral content
increased bone mineral density ( J:178743 )
• Background Sensitivity: bone mineral density is higher on the mixed BALB/cByJ and C57BL/6 background compared to F1 crosses to FVB/NJ, or C3H/HeJ but lower compared to F1 crosses to A/J
increased volumetric bone mineral density ( J:178743 )
• cortical volumetric tissue mineral density (vTMD) is elevated in the femur
decreased bone trabecula number ( J:178743 )
• fewer and more widely spaced trabeculae
decreased bone strength ( J:178743 )
• femurs are weaker and more brittle

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
osteogenesis imperfecta DOID:12347 OMIM:PS166200
 J:178743




Genotype
MGI:5300565
ht5
Allelic
Composition		 Col1a2tm1.1Mcbr/Col1a2+
Genetic
Background		 (C3H/HeJ x B6.129-Col1a2tm1.1Mcbr)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a2tm1.1Mcbr mutation (0 available); any Col1a2 mutation (120 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:178743 )

skeleton
decreased bone mineral content ( J:178743 )
• decreased bone mineral content
• lower cortical volumetric tissue mineral content
increased bone mineral density ( J:178743 )
• Background Sensitivity: bone mineral density is lowest on the mixed C3H/HeJ and C57BL/6 background compared to F1 crosses to A/J, BALB/cByJ, or FVB/NJ
increased volumetric bone mineral density ( J:178743 )
• cortical volumetric tissue mineral density (vTMD) is elevated in the femur
decreased bone trabecula number ( J:178743 )
• fewer and more widely spaced trabeculae
decreased bone strength ( J:178743 )
• femurs are weaker and more brittle

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
osteogenesis imperfecta DOID:12347 OMIM:PS166200
 J:178743




Genotype
MGI:5300566
ht6
Allelic
Composition		 Col1a2tm1.1Mcbr/Col1a2+
Genetic
Background		 (FVB/NJ x B6.129-Col1a2tm1.1Mcbr)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a2tm1.1Mcbr mutation (0 available); any Col1a2 mutation (120 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:178743 )

skeleton
increased bone mineral density ( J:178743 )
• Background Sensitivity: bone mineral density is higher on the mixed FVB/NJ and C57BL/6 background compared to F1 crosses to C3H/HeJ but lower compared to F1 crosses to A/J or BALB/cByJ
increased volumetric bone mineral density ( J:178743 )
• cortical volumetric tissue mineral density (vTMD) is elevated in the femur
decreased bone trabecula number ( J:178743 )
• fewer and more widely spaced trabeculae
decreased bone strength ( J:178743 )
• femurs are weaker and more brittle

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
osteogenesis imperfecta DOID:12347 OMIM:PS166200
 J:178743




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory