Phenotypes associated with this allele

• Allele Symbol: Hey2^tm1Eno
• Allele Name: targeted mutation 1, Eric N Olson
• Allele ID: MGI:3711158
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hey2^tm1Eno/Hey2^tm2Eno Tg(Nkx2-5-cre)9Eno/0	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:3711334
cn2	Hey2^tm1Eno/Hey2^tm2Eno Tg(Tagln-cre)1Her/0	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:3711335
cn3	Hey2^tm1Eno/Hey2^tm2Eno Tg(Tek-cre)1Ywa/0	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:3711336

Genotype
MGI:3711334

cn1

• Allelic Composition: Hey2^tm1Eno/Hey2^tm2Eno; Tg(Nkx2-5-cre)9Eno/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:121577 )

N

enlarged heart ( J:121577 )

• adult mice have grossly enlarged hearts

abnormal heart ventricle morphology ( J:121577 )

• base of dilated right ventricle merges with interventricular septum above apex of heart; this is apparent by E13.5 and persists in adults

• at 6 weeks of age, ectopic activation of atrial regular and structural genes (>10-fold greater than wild-type littermates) is observed in ventricular myocardium

abnormal interventricular septum morphology ( J:121577 )

• VSDs are not observed in all mice, however, some show VSDs or delay of ventricular septal formation at E13.5-17.5

abnormal heart left ventricle morphology ( J:121577 )

• at 6 weeks of age, mice show an increase in systolic left ventricular internal diameter (LVID)

• normal diastolic left ventricular internal diameter does not change significantly relative to wild-type

• atrial naturietic factor (ANF) and Tbx5 expression is increased in left ventricle at E17.5, whereas expression is seen in atria and trabecular cells in wild-type

dilated heart right ventricle ( J:121577 )

decreased cardiac muscle contractility ( J:121577 )

• deterioration in heart contractility, accompanied by decreased fractional shortening (FS)

muscle

decreased cardiac muscle contractility ( J:121577 )

• deterioration in heart contractility, accompanied by decreased fractional shortening (FS)

growth/size/body

enlarged heart ( J:121577 )

• adult mice have grossly enlarged hearts

Genotype
MGI:3711335

cn2

• Allelic Composition: Hey2^tm1Eno/Hey2^tm2Eno; Tg(Tagln-cre)1Her/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

mortality/aging

perinatal lethality, incomplete penetrance ( J:121577 )

• mice display partial perinatal lethality

cardiovascular system

ventricular septal defect ( J:121577 )

• VSDs are observed

dilated heart right ventricle ( J:121577 )

decreased cardiac muscle contractility ( J:121577 )

• contractile dysfunction observed

muscle

decreased cardiac muscle contractility ( J:121577 )

• contractile dysfunction observed

Genotype
MGI:3711336

cn3

• Allelic Composition: Hey2^tm1Eno/Hey2^tm2Eno; Tg(Tek-cre)1Ywa/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

mortality/aging

mortality/aging ( J:121577 )

N • mice are viable

cardiovascular system

cardiovascular system phenotype ( J:121577 )

N • no detectable defects of cardiac structure are found