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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cks1btm1Sir
targeted mutation 1, Steven I Reed
MGI:3711167
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cks1btm1Sir/Cks1btm1Sir Not Specified MGI:3711761
ht2
 		Cks1btm1Sir/Cks1b+ Not Specified MGI:3711762
cx3
 		Cks1btm1Sir/Cks1btm1Sir
Tg(IghMyc)22Bri/? 		involves: C57BL * C57BL/6 * SJL MGI:3711763
cx4
 		Cks1btm1Sir/Cks1b+
Tg(IghMyc)22Bri/? 		involves: C57BL * C57BL/6 * SJL MGI:3711765


Genotype
MGI:3711761
hm1
Allelic
Composition		 Cks1btm1Sir/Cks1btm1Sir
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cks1btm1Sir mutation (0 available); any Cks1b mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:121692 )
N
• males and females are fertile

growth/size/body
decreased body weight ( J:121692 )
• mice are about 10% to 20% smaller than wild-type at E13.5 and continuing through adulthood

cellular
early cellular replicative senescence ( J:121692 )
• derived MEF cells grow slower and senesced earlier than wild-type MEFs




Genotype
MGI:3711762
ht2
Allelic
Composition		 Cks1btm1Sir/Cks1b+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cks1btm1Sir mutation (0 available); any Cks1b mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:121692 )
• intermediate decrease in body weight compared to Cks1btm1Sir homozygotes first noticeable during embryogenesis though to a lesser extent




Genotype
MGI:3711763
cx3
Allelic
Composition		 Cks1btm1Sir/Cks1btm1Sir
Tg(IghMyc)22Bri/?
Genetic
Background		 involves: C57BL * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cks1btm1Sir mutation (0 available); any Cks1b mutation (12 available)
Tg(IghMyc)22Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:121564 )
• mean survival after lymphomas develop is 268 days compared to 91 days in Tg(IghMyc)22Bri mice and 101 days in Tg(IghMyc)22Bri Cks1btm1Sir heterozygotes

neoplasm
decreased metastatic potential ( J:121564 )
• only 1 of 9 diseased mice show moderate bone marrow infiltration and none presented with liver or meningeal infiltrates present in Tg(IghMyc)22Bri mice
increased lymphoma incidence ( J:121564 )
• delayed development of lymphomas compared to Tg(IghMyc)22Bri mice

immune system
decreased B cell proliferation ( J:121564 )
• severely impaired proliferative response compared to Tg(IghMyc)22Bri mice
decreased lymphocyte cell number ( J:121564 )
• 5.4+/-0.4x106ul compared to 6.9+/-0.4x106ul in Tg(IghMyc)22Bri mice
decreased spleen weight ( J:121564 )
• at 4 weeks, mice have significantly smaller spleens than Tg(IghMyc)22Bri counter parts (83+/-11mg compared to 157+/-7mg)

hematopoietic system
decreased B cell proliferation ( J:121564 )
• severely impaired proliferative response compared to Tg(IghMyc)22Bri mice
decreased lymphocyte cell number ( J:121564 )
• 5.4+/-0.4x106ul compared to 6.9+/-0.4x106ul in Tg(IghMyc)22Bri mice
decreased spleen weight ( J:121564 )
• at 4 weeks, mice have significantly smaller spleens than Tg(IghMyc)22Bri counter parts (83+/-11mg compared to 157+/-7mg)

cellular
decreased B cell proliferation ( J:121564 )
• severely impaired proliferative response compared to Tg(IghMyc)22Bri mice




Genotype
MGI:3711765
cx4
Allelic
Composition		 Cks1btm1Sir/Cks1b+
Tg(IghMyc)22Bri/?
Genetic
Background		 involves: C57BL * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cks1btm1Sir mutation (0 available); any Cks1b mutation (12 available)
Tg(IghMyc)22Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:121564 )
• mean survival after lymphomas development is 101 days

neoplasm




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory