Phenotypes associated with this allele

• Allele Symbol: Kdm1a^tm1.1Rsd
• Allele Name: targeted mutation 1.1, Michael G Rosenfeld
• Allele ID: MGI:3711205
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kdm1a^tm1.1Rsd/Kdm1a^tm1.1Rsd Tg(Pitx1-cre)7Rsd/0	involves: BALB/c * C57BL/6	MGI:3711646

Genotype
MGI:3711646

cn1

• Allelic Composition: Kdm1a^tm1.1Rsd/Kdm1a^tm1.1Rsd; Tg(Pitx1-cre)7Rsd/0
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pituitary gland development ( J:121427 )

• beginning on E13.5, pituitary glands have increased numbers of luminal cells in S phase relative to controls

• at E17.5, glands show a convoluted lumen and exhibit higher proliferation of luminal cells

nervous system

nervous system phenotype ( J:121427 )

N

abnormal pituitary gland development ( J:121427 )

• beginning on E13.5, pituitary glands have increased numbers of luminal cells in S phase relative to controls

• at E17.5, glands show a convoluted lumen and exhibit higher proliferation of luminal cells

homeostasis/metabolism

abnormal pituitary hormone level ( J:121427 )

• few pro-opiomelanocortin-positive cells (POMCs) are detected in the pituitary gland, resulting in decreased protein levels

decreased growth hormone level ( J:121427 )

• protein levels are barely detectable relative to wild-type

abnormal luteinizing hormone level ( J:121427 )

• few LH-positive cells are detected in the pituitary gland resulting in decreased protein levels in pituitary

decreased thyroid-stimulating hormone level ( J:121427 )

• protein levels are barely detectable relative to wild-type

cellular

abnormal cell cycle ( J:121427 )

• more cells in lumen are in S phase at ~E13.5 relative to controls

• some cell cycle regulation genes are upregulated in mutants at E17.5